Advances in Therapy

, Volume 24, Issue 3, pp 603–610

Interleukin-10 and -12 in human milk at 3 stages of lactation: A longitudinal study

  • H. Levent Yilmaz
  • Esra Selver Saygili-Yilmaz
  • Ramazan Gunesacar


This study was undertaken to analyze postpartum changes in concentrations of interleukin (IL)-10 and IL-12 through the 3 stages of lactation. A total of 87 human milk samples were collected from 29 healthy mothers during the colostrum (0–3 days), early milk (14–17 days), and mature milk (44–47 days) phases. Enzyme-linked immunosorbent assay tests were performed on the milk samples. IL-10 was detected in 7 and IL-12 in 4 of the colostrum samples. In the transitional milk samples, IL-10 was present in 4 and IL-12 in 2; however, both of these cytokines became undetectable in mature milk samples. The decrease in concentrations of IL-10 and IL-12 was statistically significant during the postpartum period (P=.001 and P=.024, respectively). IL-10 levels in the colostrum samples were higher than in the transitional samples (P=.018, with use of the post hoc test). No statistically significant differences between IL-12 levels were noted in the colostrum samples and the transitional samples (P=.068, with use of the post hoc test). A negative correlation was observed between concentrations of IL-10 in colostrum and the total number of pregnancies (R=−.401;P=.031). The findings of the present study suggest that mean concentrations of IL-10 and IL-12 are decreased in human milk as lactation continues through its 3 phases.


human milk interleukin-10 interleukin-12 lactation cytokines 


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Copyright information

© Health Communications Inc 2007

Authors and Affiliations

  • H. Levent Yilmaz
    • 1
  • Esra Selver Saygili-Yilmaz
    • 2
  • Ramazan Gunesacar
    • 3
  1. 1.Department of Pediatric Emergency MedicineMedical Faculty of Cukurova UniversityTurkey
  2. 2.Department of Obstetrics and GynecologySeyhan Research and Education Hospital Numune Research HospitalTurkey
  3. 3.Department of Rheumatology-ImmunologyMedical Faculty of Cukurova UniversityAdanaTurkey

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