Biosynthesis of furanochromones inPimpinella monoica

  • D. L. Luthria
  • A. Banerji
Biosynthesis, Enzyme Structure and Applications


During a search for bioactive compounds from indigenous plants,Pimpinella monoica (Umbelliferae) was found to contain furocoumarin, isopimpenellin (3) and five biogenetically related furocoumarins viz khellin (1), visnagin (2), visamminol (4), ammiol (5) and khellol (6). Labelled (i) and (2) were isolated from [1−14C]- and [2−14C]-acetates. Labelling pattern, determined by degradation of biosynthesised compounds, establishes the polyketide origin of their aromatic and pyrone rings while the furan ring originates via an acetate-mevalonate pathway. The plant also utilises glycine and leucine as substratevia acetate. Biotransformation of [3−3H]-visnagin to (6) but not to (2) was also observed.


Biosynthesis furochromones polyketide origin [3−3H]-visnagin khellin 


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Copyright information

© Indian Academy of Sciences 1994

Authors and Affiliations

  • D. L. Luthria
    • 1
  • A. Banerji
    • 1
  1. 1.Bio-Organic DivisionBhabha Atomic Research CentreBombayIndia

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