MRS study on lentiform nucleus in idiopathic Parkinson’s disease with unilateral symptoms
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Objective: To investigate changes in magnetic resonance spectroscopy (MRS) of lentiform nucleus during the early stage of Parkinson’s disease. Methods: Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study. MRS of the lentiform nucleus in each patient was taken and then concentrations of N-acetylaspartate (NAA), Creatine (Cr) and Choline, (Cho) were calculated. Results: Compared to that in the control, NAA/(Cho+Cr) was significantly lower in the lentiform nucleus contralateral to symptoms and even that in the ipsilateral side in IPDUS patients (allP<0.05); while there was no difference between the two sides in the healthy volunteer (P>0.05). The ratio of NAA/(Cho+Cr) ipsilateral to the sympatomatic side of the patient was also lower than that of the controll (P<0.05). Conclusions: there might be some changes with MRS on the lentiform nucleus during the early stage of idiopathic Parkinson’s disease with unilateral symptom. MRS may be one of the reliable methods for early or even sub-clinical diagnosis.
Key wordsIdiopathic Parkinson’s disease with unilateral symptom (IPDUS) Magnetic resonance spectroscopy N-acetyaspartate Creatine Choline
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- Brooks, D.J., 2000. Morphological and functional imaging studies on the diagnosis and progression of Parkinson’s disease.J Neurol,247(2):II11–18.Google Scholar
- Ellis, C.M., Lemmens, G., Williams, S.C., Simmons, A., Dawson, J., Leigh, P.N., Chaudhuri, K.R., 1997. Changes in putamen N-acetylaspartate and Choline ratios in untreated and levodopa-treated Parkinson’s disease: a proton magnetic resonance spectroscopy study.Neurology.,49(2):438–444.CrossRefGoogle Scholar
- National Extrapyramidal Session, 1986. The diagnosis criteria and differential diagnosis of Parkinson’s disease and Parkinson’s syndromes.Chin J Neurol Psychiatry,19(5):256(in Chinese).Google Scholar
- Ronald, F., 1990. Therapy of Parkinson’s Disease. Marcel Dekker Inc, New York, p. 95–120.Google Scholar