Folia Microbiologica

, Volume 37, Issue 2, pp 153–156 | Cite as

Functional and metabolic changes of guinea pig peritoneal macrophages induced by bacterial vaccines

  • J. Takáčová
  • D. Kotulová
  • A. Kašičková
  • M. Ferenčík
Papers
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Abstract

Phagocytic activity of peritoneal macrophages of guinea pigs injected subcutaneously with bacterial vaccines was found to be increased. The phagocytic index remained unchanged or was decreased. In addition, a decreased candidacidal activity was observed. Metabolic activation of macrophages, measured by the INT test, was inhibited in unstimulated cells while cells stimulated with zymosan or opsonized zymosan exhibited higher values of the INT test as compared with control animals. After injection of vaccines the number of peritoneal macrophages was increased, but the spleen mass decreased.

Keywords

Peritoneal Macrophage Phagocytic Activity Physiological Solution Phagocytic Index Phage Lysate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Folia Microbiologica 1992

Authors and Affiliations

  • J. Takáčová
    • 1
  • D. Kotulová
    • 2
  • A. Kašičková
    • 3
  • M. Ferenčík
    • 3
  1. 1.Department of Clinical BiochemistryHospital with PoliclinicLevočaCzechoslovakia
  2. 2.Department of Medical Microbiology and ImmunologyComenius UniversityBratislavaCzechoslovakia
  3. 3.Institute of ImmunologyComenius UniversityBratislavaCzechoslovakia

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