Advertisement

Chinese Journal of Integrative Medicine

, Volume 11, Issue 3, pp 187–190 | Cite as

Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure

  • Zhang Jin-guoEmail author
  • Yang Na
  • He Hua
  • Wei Guang-he
  • Gao Dong-sheng
  • Wang Xiao-li
  • Wang Xue-zhong
  • Song Guang-yao
Original Articles

Abstract

Objective: To investigate the effect of Astragalus injection (AI) on plasma levels of apoptosis-related factors in aged patients with chronic heart failure (CHF).Methods: Seventy-two CHF patients were randomly divided into the AI group (36 cases) treated with AI and the control group (36 cases) treated with conventional treatment. Plasma levels of soluble Fas (sFas), soluble Fas ligand (sFasL), tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assays (ELISA) with monoclonal anti-human antibodies. Besides, New York Heart Association (NYHA) grading was assessed according to improved symptoms and left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV) and left ventricular ejection fraction (LVEF) were assessed by echocardiogram after 4 weeks of treatment.Results: After 4 weeks of treatment, NYHA grading was markedly improved in the two groups, but it was significantly better in AI group than that in the control group (P<0.05). As compared with the control group, sFas, sFasL,TNF-α and IL-6 in the AI group were obviously lower, the difference between the two groups and between before and after treatment were significant (P<0.05 orP 0.01). Moreover, in AI group, LVESV and LVEDV decreased, LVEF increased, which was significantly different than that before treatment (P<0.05), respectively.Conclusion: AI could lower plasma levels of apoptosis-related factors, and is one of the effective drugs in improving cardiac function in the aged patients with CHF.

Key Words

chronic heart failure the aged apoptosis cytokines Astragalus injection 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Sasayama S, Matsumori A. Role of cytokines in the syndrome of heart failure. Intern Med 1996;35 (1): 60–63.CrossRefGoogle Scholar
  2. 2.
    Kang PM, Izumo S. Apoptosis and heart failure. Circ Res 2000; 86(11): 1107–1113.PubMedGoogle Scholar
  3. 3.
    Mckee PA, Castell WP, Mcnamara PM, et al. The natural history of congestive heart failure, the Framingham study. N Engl J Med 1971;285(26): 1444–1452.CrossRefGoogle Scholar
  4. 4.
    Chen QM, Tu VC. Apoptosis and heart failure: mechanisms and therapeutic implications. Am J Cardiovas Drugs 2002;2(l): 43–57.CrossRefGoogle Scholar
  5. 5.
    Tsutamoto T, Wada A, Maeda K, et al. Relationship between plasma levels of cardiac natriuretic peptides and soluble Fas: plasma soluble Fas as a prognostic predictor in patients with congestive heart failure. J Cardiac Failure 2001;7(4): 322–328.CrossRefGoogle Scholar
  6. 6.
    Zhou ZL, Yu P, Lin D, et al. Study on effect of Astragalus injection in treating congestive heart failure. Chin J Integr Tradit West Med (Chin) 2001;21(10): 747–749.Google Scholar
  7. 7.
    Zhang JG, Gao DS, Yang N, et al. Effect of Astragalus injection on left ventricular remodeling in aged patients with acute early-stage myocardial infarction. Chin J Integr Med 2003;9(2): 104–107.CrossRefGoogle Scholar
  8. 8.
    Wang GY, Guo XM. Effects of Radix Astragali on the nitric oxide, free radicals and apoptosis of thymus in aging mice. J Mudanjiang Med Coll 2004;25(4): 14–15.Google Scholar
  9. 9.
    Song DJ, Gu GD, Mao SY, et al. Effect of Astragalus membranaceus on spontaneously hypertensive rats. Chin Tradit Herbal Drugs 1989;20(8): 25–28.Google Scholar
  10. 10.
    Zhong F, Du JZ, Yu XH, et al. Effect of Astragaloside on apoptosis in viral myocarditis. J Nanhua Univ (Med ed) 2004;32(l): 17–19.Google Scholar
  11. 11.
    Jiang LM, Li W, Wei KL. Effects of Astragalus Injection on perforin in myocardial infiltrating cell and expression of FasL mRNA in mice with acute myocarditis. For Med (Fascicle of Pediatrics) 2003;30(2): 111–112.Google Scholar
  12. 12.
    Liu ZG, Xiong ZM, Yu XY. Effect of Astragalus Injection on immune function in patients with congestive heart failure. Chin J Integr Tradit West Med (Chin) 2003;23(5): 351–353.Google Scholar
  13. 13.
    Ruan CW, Zhang DF, Wang SS, et al, The effects of Huangqi on myocyte apoptosis and the expression of apoptosis-associated genes in rat heart with acute myocardial ischemia and reperfusion. J Tongji Univ (Med Sci) 2003;24(3): 182–184.Google Scholar

Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press 2005

Authors and Affiliations

  • Zhang Jin-guo
    • 1
    Email author
  • Yang Na
    • 2
  • He Hua
    • 1
  • Wei Guang-he
    • 1
  • Gao Dong-sheng
    • 1
  • Wang Xiao-li
    • 1
  • Wang Xue-zhong
    • 2
  • Song Guang-yao
    • 2
  1. 1.Department of CardiologyAffiliated Hospital of Jining Medical CollegeShandong
  2. 2.Department of CardiologyPeople’s Hospital of Hebei ProvinceShijiazhang

Personalised recommendations