Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo
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Objective: To study the effects of basil polysaccharide (BP) in inhibiting tumor growth and metastasis in vivo.Methods: One hundred and fifty mice were randomly divided into five groups to observe the effect on tumor growth after H22 cancer cells had been transplanted subcutaneously into their right armpit region and treated with different dosages (5 mg/kg, 2.5 mg/kg and 1.25 mg/kg) of BP for 14 days, with Mitomycin (Mit-C) used as control. Another 150 mice were randomly divided into three groups, models of tumor metastasis in the lung by various paths (lymphatic, blood circulatory and spontaneous) were established respectively. They were treated with BP or Mit-C to observe the influence of treatments on tumor metastasis by various paths.Results: BP of various dosages showed no effect on tumor growth, but in high and middle dosage, it could significantly reduce the number or metastasis nodules (P<0.05). Conclubsion: BP has a tumor metastasis inhibitory effect, which might be one of the candidates for new anti-tumor metastasis agents. Its mechanism may be blocking the function of platelets in the tumor metastasis progress.
Key WordsChinese medicine basil polysaccharide cell proliferation anti-tumor metastasis
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- 1.Ian FT, Richard PH. The Basic Science of Oncology. 3 rd edition. New York: McGran-Hill Inc, 1998,22.Google Scholar
- 3.Plotnikov MB, Maslov MIu, Aliev ol, et al. Disorders of hemorrheology in Walker’s carcinosarcoma-256 and in cyclophosphamide treatment of rats. Vopr Oncol 2001; 47(3): 335–337.Google Scholar
- 4.von Tempelhoff GF, Nieman F, Heilmann L, et al. Association between hemorrheology, thrombosis and cancer survival in patients with gynecologic malignancy. Clin Hemorrheol Microcirc 2000; 22(2): 107–130.Google Scholar
- 5.Yang ZH, Shi YL, Ran YL. Generation and characterization of monoclonal antibodies to human vascular endothelial growth factor 165 and the effect on primary and metastatic tumor growth of breast tumor. Chin J Immunol 1999; 15 (9): 414–417.Google Scholar