Genes & Nutrition

, Volume 1, Issue 2, pp 133–135 | Cite as

Polymorphisms in the Apolipoprotein L1 gene and their effects on blood lipid and glucose levels in middle age males

  • Nigel M. Page
  • Estibaliz Olano-Martin
  • Christopher Lanaway
  • Rufus Turner
  • Anne Marie Minihane
Article

Abstract

Apolipoprotein L1 in plasma is associated with high-density lipoprotein. Novel APOL1 polymorphisms are investigated along with the association of two common haplotypes (Lysl66Glu, Ile244Met, Lys271Arg) with circulating lipid and glucose levels. Although the amino acid substitutions occur in the amphipathic alpha helices region involved in lipid binding, these substitutions were found not to independently account for variability in circulating lipid and glucose levels in 149 middle age males.

Key Words

Apolipoprotein L Blood Lipids Glucose Polymorphisms 

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Copyright information

© Springer Heidelberg 2006

Authors and Affiliations

  • Nigel M. Page
    • 1
  • Estibaliz Olano-Martin
    • 2
  • Christopher Lanaway
    • 1
  • Rufus Turner
    • 2
  • Anne Marie Minihane
    • 2
  1. 1.School of Biological SciencesThe University of ReadingReadingUK
  2. 2.The Hugh Sinclair Unit of NutritionThe University of ReadingRG6 6APUK
  3. 3.School of Food BiosciencesThe University of ReadingReadingUK

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