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Folia Microbiologica

, 43:438 | Cite as

Gentamicin resistance in clinical strains ofEnterobacteriaceae associated with reduced gentamicin uptake

  • K. Adwan
  • N. Abu-Hasan
Papers

Abstract

Seven strains ofEnterobacteriaceae resistant to gentamicin obtained as representatives of the predominant resistance profiles in the clinical laboratories ofRafeidia and Al-Watani Hospitals in Nablus (Palestine) were included. Five strains showed a broad aminoglycoside resistance profile but contained no evidence of gentamicin acetylation, adenylation, or phosphorylation. Gentamicin uptake in two tested strains was significantly reduced, compared to that of gentamicin-sensitiveE. coli (MIC, 0.5 μg/mL.) These strains are likely resistant due to a relative reduction of the amount of gentamicin and other aminoglycosides entering the bacterial cell. Two strains showed evidence of adenyltransferase ANT (2")-I activity.

Keywords

Minimum Inhibitory Concentration Gentamicin Aminoglycoside Amikacin Tobramycin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1998

Authors and Affiliations

  • K. Adwan
    • 1
  • N. Abu-Hasan
    • 1
  1. 1.Department of Biological SciencesAn-Najah N. UniversityNablusPalestine

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