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Molecular Neurobiology

, Volume 9, Issue 1–3, pp 119–123 | Cite as

Mechanism of neurofibrillary degeneration in Alzheimer's disease

  • Khalid Iqbal
  • Alejandra del C. Alonso
  • Cheng-Xin Gong
  • Sabiha Khatoon
  • Toolsee J. Singh
  • Inge Grundke-Iqbal
Article

Abstract

Neurofibrillary degeneration associated with the formation of intraneuronal neurofibrillary tangles of paired helical filaments (PHF) and 2.1 nm τ filaments is one of the most characteristic brain lesions of Alzheimer's disease. The major polypeptides of PHF are the microtubule associated protein, τ. τ, in PHF is present in abnormally phosphorylated forms. In addition to the PHF, the abnormal τ is present in soluble non-PHF form in the alzheimer's disease brain. The level of τ in Alzheimer's disease neocortex is severalfold higher than in aged control brain, and this increase is in the form of the abnormally phosphorylated protein. The abnormally phosphorylated τ does not promote the assembly of tubulin into microtubules in vitro, and it inhibits the normal τ-stimulated microtubule assembly. After in vitro dephosphorylation both PHF and non-PHF abnormal τ stimulate the assembly of tubulin into microtubules. The activities of phosphoseryl/phosphothreonyl protein phosphatase 2A and nonreceptor phosphotyrosyl phosphatase(s) are decreased in AD brain. It is suggested that
  1. 1.

    A defect(s) in the protein phosphorylation/dephosphorylation system is one of the early events in the neurofibrillary pathology in AD;

     
  2. 2.

    A decrease in protein phosphatase, activities, at least in part, allows the hyperphosphorylation of τ; and

     
  3. 3.

    Abnormal phosphorylation and polymerization of τ into PHF most probably lead to a breakdown of the microtubule system and consequently to neuronal degeneration.

     

Index Entries

Alzheimer's disease mechanisms of neuronal degeneration neurofibrillary changes paired helical filaments biochemistry microtubule-associated protein τ abnormal phosphorylation ubiquitination microtubule assembly axoplasmic flow protein phosphorylation/dephosphorylation 

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Copyright information

© Human Press Inc 1994

Authors and Affiliations

  • Khalid Iqbal
    • 1
  • Alejandra del C. Alonso
    • 1
  • Cheng-Xin Gong
    • 1
  • Sabiha Khatoon
    • 1
  • Toolsee J. Singh
    • 1
  • Inge Grundke-Iqbal
    • 1
  1. 1.New York State Institute for Basic Research in Developmental DisabilitiesStaten Island

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