Molecular and Chemical Neuropathology

, Volume 33, Issue 1, pp 15–26 | Cite as

Ascorbate-stimulated lipid peroxidation and non-heme iron concentrations in Alzheimer disease

  • Anne C. Andorn
  • Robert S. Britton
  • Bruce R. Bacon
  • Rajesh N. Kalaria
Original Articles

Abstract

Lipid peroxidation has been suggested to be a potential cause of neuronal damage in neurodegenerative diseases. Changes in several parameters of lipid peroxidation, including basal (unstimulated) lipid peroxidation, stimulated lipid peroxidation, tissue iron concentrations, and the concentrations of some oxygen radical scavengers, have been reported in neurodegenerative diseases. However, the in vitro interaction of oxygen radical scavengers and stimulated lipid peroxidation in neurodegenerative disease has been less wellstudied. The purpose of the present study was to determine the effects of oxygen radical scavengers on ascorbate-stimulated lipid peroxidation in Alzheimer disease (AD). We have found that some parameters of ascorbate-stimulated lipid peroxidation are altered in AD and that the effects of superoxide dismutase (SOD) on ascorbatestimulated lipid peroxidation are significantly different in AD as compared to aged.

Index Entries

Alzheimer disease lipid peroxidation iron brain antioxidants aging 

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Copyright information

© Humana Press Inc 1998

Authors and Affiliations

  • Anne C. Andorn
    • 1
    • 3
  • Robert S. Britton
    • 2
  • Bruce R. Bacon
    • 2
  • Rajesh N. Kalaria
    • 4
  1. 1.Department of PsychiatrySaint Louis University School of MedicineSt. Louis
  2. 2.Division of Gastroenterology and Hepatology, Department of Internal MedicineSaint Louis University School of MedicineSt. Louis
  3. 3.Psychiatry ServiceSt. Louis VAMCSt. Louis
  4. 4.Department of Neurology, Case Western ReserveUniversity School of MedicineCleveland

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