Molecular and Chemical Neuropathology

, Volume 28, Issue 1–3, pp 15–20

Species differences in the generation of reactive oxygen species by microglia

  • Carol Colton
  • Susan Wilt
  • Daniel Gilbert
  • Olga Chernyshev
  • Julie Snell
  • Monique Dubois-Dalcq
Part II Free Radical Mechanisms in Neurodegenerative Disorders—A Common Pathogenesis?

DOI: 10.1007/BF02815200

Cite this article as:
Colton, C., Wilt, S., Gilbert, D. et al. Molecular and Chemical Neuropathology (1996) 28: 15. doi:10.1007/BF02815200

Abstract

Although a variety of potential sources for reactive oxygen species (ROS) exist in the CNS, brain macrophages, i.e., the microglia, generate large quantities of these reactive species, particularly in response to injury or inflammatory signals. In order to understand how microglia contribute to changes in oxidative status of the CNS and how this might relate to disease states, such as Alzheimer disease (AD), we have examined the regulation of superoxide anion and nitric oxide production from rodent and human microglia. Our results indicate that microglia from all species we have studied release superoxide anion, but produce significantly different amounts in response to the same activating agents. Species differences are also found in the ability to generate nitric oxide (NO). In particular, mouse microglia generate large quantities of NO when stimulated, but human and hamster microglia do not produce measurable amounts under the same stimulation conditions. These species differences are important to consider when modeling human disease processes from rodent studies.

Index Entries

Macrophages microglia reactive oxygen species Alzheimer disease inflammation superoxide anion nitric oxide 

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Copyright information

© Humana Press Inc. 1996

Authors and Affiliations

  • Carol Colton
    • 1
  • Susan Wilt
    • 2
  • Daniel Gilbert
    • 3
  • Olga Chernyshev
    • 1
  • Julie Snell
    • 3
  • Monique Dubois-Dalcq
    • 2
  1. 1.Department of Physiology and BiophysicsGeorgetown University Medical SchoolWashington, DC
  2. 2.Department de VirologieInstitute PasteurParisFrance
  3. 3.Unit of Reactive Oxygen Species, Biophysics Section, NINDSNIHBethesda

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