Molecular Neurobiology

, Volume 17, Issue 1–3, pp 87–108 | Cite as

Corticosteroids in the brain

Cellular and molecular actions
  • Marian JoËls
  • Erno Vreugdenhil
Original Articles

Abstract

The rat adrenal hormone corticosterone reaches the brain and binds to intracellular receptors. These receptors comprise high-affinity mineralocorticoid and lower-affinity glucocorticoid receptors that, upon activation, affect the transcription rate of specific genes. The two receptor types are discretely localized in the brain, with particularly high expression levels in the hippocampus. Here we review recent studies showing that electrical properties and structural aspects of hippocampal principal neurons are specifically regulated by mineralocorticoid- or glucocorticoid-receptor activation. The molecular mechanisms by which these cellular effects could be accomplished are discussed.

Index Entries

Corticosteroid hormones mineralocorticoid receptor glucocorticoid receptor signal transduction morphology hippocampus 

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Copyright information

© Humana Press Inc 1998

Authors and Affiliations

  • Marian JoËls
    • 1
  • Erno Vreugdenhil
    • 2
  1. 1.Graduate School Neurosciences AmsterdamInstitute for NeurobiologyThe Netherlands
  2. 2.Division of Medical PharmacologyLeiden Amsterdam Center of Drug ResearchThe Netherlands

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