Molecular Neurobiology

, Volume 17, Issue 1–3, pp 73–86

Cellular and molecular basis of estrogen’s neuroprotection

Potential relevance for Alzheimer’s disease
  • Nibaldo C. Inestrosa
  • Maria-Paz Marzolo
  • Andrea B. Bonnefont
Original Articles


Alzheimer’s disease (AD) is one of the most common types of dementia among the aged population, with a higher prevalence in women. The reason for this latter observation remained unsolved for years, but recent studies have provided evidence that a lack of circulating estrogen in postmenopausal women could be a relevant factor.

Moreover, follow-up studies among postmenopausal women who had received estrogenreplacement therapy (ERT), suggested that they had a markedly reduced risk of developing AD. In addition, studies among older women who already had AD indeed confirmed that a decrease in estrogen levels was likely to be an important factor in triggering the pathogenesis of the disease.

In this review article, we will discuss the evidence suggesting that estrogen may have a protective role against AD, mainly through its action as: a trophic factor for cholinergic neurons, a modulator for the expression of apolipoprotein E (ApoE) in the brain, an antioxidant compound decreasing the neuronal damage caused by oxidative stress, and a promoter of the physiological nonamyloidogenic processing of the amyloid precursor protein (APP), decreasing the production of the amyloid-Β-peptide (AΒ), a key factor in the pathogenesis of AD.

Index Entries

Neuroprotection estrogen cholinergic neurons apolipoprotein E APP processing oxidative stress Alzheimer’s disease 


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Copyright information

© Humana Press Inc 1998

Authors and Affiliations

  • Nibaldo C. Inestrosa
    • 1
  • Maria-Paz Marzolo
    • 1
  • Andrea B. Bonnefont
    • 1
  1. 1.Departamento de Biología Celular y Molecular, Facultad de Ciencias BiológicasPontificia Universidad Católica de ChileChile

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