Biological Trace Element Research

, Volume 47, Issue 1–3, pp 307–311

Pentoxifylline

A hydroxyl radical scavenger
  • J. P. Freitas
  • P. M. Filipe
Part X Environment and Side Effects of Drugs

DOI: 10.1007/BF02790131

Cite this article as:
Freitas, J.P. & Filipe, P.M. Biol Trace Elem Res (1995) 47: 307. doi:10.1007/BF02790131

Abstract

Pentoxifylline (PTX), a tri-substituted purine and xanthine derivative, has been used for several years to improve microcirculation because of its hemorheological properties. PTX has also antifibrotic and anti-inflammatory effects. We studied the reaction of PTX with the hydroxyl radical and superoxide anion. Hydroxyl radical was generated by a mixture of ascorbic acid, H2O2 and Fe (III)-EDTA. We evaluated the iron-dependent degradation of deoxyribose, mediated by hydroxyl radical, in the presence of different concentrations of PTX (from 0.05 to 3 mM), measuring the degradation products of deoxyribose that react with 2-thiobarbituric acid (TBA). The reaction of PTX with hydroxyl radical occurred with a rate constant of (1.1±0.2)×1010M−1/s. These results support the properties of PTX as a hydroxyl radical scavenger. Some authors verified that PTX decreases the release of superoxide anion from activated neutrophils. We studied the effect of PTX as a scavenger of superoxide generated in vitro by a hypoxanthine-xanthine oxidase system. PTX was not a superoxide anion scavenger in this system.

Index Entries

Pentoxifylline hydroxyl radical superoxide anion 

Copyright information

© Humana Press Inc. 1995

Authors and Affiliations

  • J. P. Freitas
    • 1
  • P. M. Filipe
    • 1
  1. 1.Faculdade de Medicina de LisboaClínica Dermatológica UniversitáriaLisboaPortugal

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