Different tissue responses for iodine and iodide in rat thyroid and mammary glands

  • Bernard A. Eskin
  • Carolyn E. Grotkowski
  • Christopher P. Connolly
  • William R. Ghent
Original Articles


This research describes the effects of short-term elemental iodine (I2) and iodide (I) replacement on thyroid glands and mammary glands of iodine-deficient (ID) Sprague-Dawley female rats. Iodine deficiency causes atypical tissue and physiologic changes in both glands. Tissue histopathology and the endocrine metabolic parameters, such as serum TT4, tissue and body weights, and vaginal smears, are compared. A moderate reduction in thyroid size from the ID control (IDC) was noted with both I and I2, whereas serum total thyroxine approached the normal control with both I and I2, but was lower in IDC. Thyroid gland IDC hyperplasia was reduced modestly with I2, but eliminated with I. Lobular hyperplasia of the mammary glands decreased with I2 and increased with I when compared with the IDC; extraductal secretions remained the same as IDC with I2, but increased with I; and periductal fibrosis was markedly reduced with I2, but remained severe with I. Thus, orally administered I2 or I in trace doses with similar iodine availability caused different histopathological and endocrine patterns in thyroid and mammary glands of ID rats. The significance of this is that replacement therapy with various forms of iodine are tissue-specific.

Index Entries

Iodine iodide thyroid gland mammary glands rats iodine deficiency 


  1. 1.
    N. Freinkel and S. H. Ingbar,Endocrinology 58, 51 (1956).PubMedGoogle Scholar
  2. 2.
    R-D. Hesch and J. Koehrle, in Werner'sThe Thyroid, 5th ed. S. H. Ingbar and L. E. Braverman, eds., Lippincott, Philadelphia, pp. 154–200 (1986).Google Scholar
  3. 3.
    K. D. Thrall and R. J. Bull,Fundam. Appl. Toxicol. 15(1), 75–81 (1990).PubMedCrossRefGoogle Scholar
  4. 4.
    K. D. Thrall, R. J. Bull, and R. L. Sauer,J. Toxicol. Environ. Health 37, 443–449 (1992).PubMedCrossRefGoogle Scholar
  5. 5.
    B. A. Eskin,Trans. NY Acad Sci. 32, 911–947 (1970).Google Scholar
  6. 6.
    J. M. Strum,Anat. Rec. 192, 235–244 (1978).PubMedCrossRefGoogle Scholar
  7. 7.
    B. A. Eskin, C. E. Sparks, and B. I. LaMont,Biol. Trace Element Res. 1, 101 (1979).Google Scholar
  8. 8.
    N. M. Shah, B. A. Eskin, T. B. Krouse, and C. E. Sparks,Proc. Soc. Exp. Biol. 181, 443 (1986).Google Scholar
  9. 9.
    B. A. Eskin, R. Shuman, T. Krouse, and J. Merion,CA Res. 35, 2332 (1975).Google Scholar
  10. 10.
    T. B. Krouse, B. A. Eskin, and J. Mobini,Arch. Pathol. Lab. Med. 103, 631–634 (1979).PubMedGoogle Scholar
  11. 11.
    J. M. Strum,Virchows Archiv.-B-Cell Pathol. 30(2), 209–220 (1979).Google Scholar
  12. 12.
    B. A. Eskin, T. B. Krouse, P. R. Modhera, and M. A. Mitchell, inFrontiers in Thyroidology, vol. 1, G. Medeiro-Neto and E. Gaitan, eds, Plenum, New York, p. 1027 (1986).Google Scholar
  13. 13.
    T. I. Aquino and B. A. Eskin,Arch. Pathol. 94, 280 (1972).PubMedGoogle Scholar
  14. 14.
    W. R. Ghent, B. A. Eskin, D. A. Low, and L. P. Hill.Can. J. Surg. 36(5), 453–460 (1993).PubMedGoogle Scholar
  15. 15.
    J. Russo, B. A. Gusterson, A. E. Rogers, I. Russo, S. R. Wellings, and M. J. vanZwufer,Lab. Invest. 62, 244 (1990).PubMedGoogle Scholar
  16. 16.
    G. D. Potter, W. Tong, and I. L. Chaikoff,J. Biol. Chem. 234, 350–354 (1959).PubMedGoogle Scholar
  17. 17.
    B. K. Vonderhaar and A. E. Greco,Endocrinology 104(2), 409 (1979).PubMedCrossRefGoogle Scholar
  18. 18.
    J. M. Strum, P. C. Phelps, and M. M. McAtee,J. Ultrastruct. Res. 84, 130–139 (1983).PubMedCrossRefGoogle Scholar
  19. 19.
    K. Brown-Grant,J. Physiol. 135, 644 (1957).PubMedGoogle Scholar
  20. 20.
    A. Clur,Med. Hyp. 27, 303–311 (1988).CrossRefGoogle Scholar
  21. 21.
    E. R. DeSombre and R. C. Lyttle,CA Res. 38, 4086–4090 (1978).Google Scholar

Copyright information

© Humana Press Inc 1995

Authors and Affiliations

  • Bernard A. Eskin
    • 1
  • Carolyn E. Grotkowski
    • 2
  • Christopher P. Connolly
    • 1
  • William R. Ghent
    • 3
  1. 1.Department of Obstetrics and GynecologyMedical College of PennsylvaniaPhiladelphia
  2. 2.Department of PathologyMedical College of PennsylvaniaPhiladelphia
  3. 3.Department of SurgeryQueen's UniversityKingstonCanada

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