Biological Trace Element Research

, Volume 51, Issue 2, pp 161–168 | Cite as

Protective effects of GSH, vitamin E, and selenium on lipid peroxidation in cadmium-fed rats

  • S. V. S. Rana
  • Seema Verma


Increased intake of Cd results in its retention and in peroxidative damage in soft tissues. Coadministration of antioxidants, viz., glutathione (GSH), α-tocopherol, and Se, restricted the uptake and distribution of Cd in liver and kidney of rats. Moreover, no rise in malondialdehyde was recorded. Although possible antioxidative mechanisms manifested by GSH, α-tocopherol, and Se have been discussed, it is hypothesized that GSH functions as a Cd chelator. Glutathione yielded favorable effects in comparison to Se and α-tocopherol.

Index Entries

Cadmium glutathione α-tocopherol selenium malondialdehyde 


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Copyright information

© Humana Press Inc. 1996

Authors and Affiliations

  • S. V. S. Rana
    • 1
  • Seema Verma
    • 1
  1. 1.Department of ZoologyCh. Charan Singh UniversityMeerutIndia

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