Biological Trace Element Research

, Volume 55, Issue 3, pp 307–314

Determination of urinary zinc, chromium, and copper in steel production workers

  • C. J. Horng
  • S. R. Lin
Article

Abstract

The aim of our investigation was to determine the concentrations of Cu, Zn, and Cr in urine samples under routine clinical laboratory conditions. To asses the reliability of these methods, critical factors such as detection limit(s), calibration range(s), cost, accuracy, and precision were studied. Our method was employed for the quantitative determination of zinc, chromium, and copper in urine samples from steel production and quality control (QC) workers and healthy unexposed controls. After pretreatment with acids, the samples were digested via a microwave oven. Zinc was determined by flame absorption spectrophotometry (FAAS), whereas chromium and copper were determined by a graphite-furnace atomic absorption spectrophotometry (GFAAS). Our results indicate that urinary zinc, chromium, and copper levels of the exposed workers are significantly higher than those of the controls. The possibility that these metals are involved in the etiology of diseases is discussed and recommendations are made to improve workplace ventilation and industrial hygiene practices.

Index Entries

Steel production workers atomic absorption spectrometry zinc chromium copper urine specimens 

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References

  1. 1.
    A. M. Bond and J. B. Reust,Anal. Chem. Acta 162, 389–392 (1984).CrossRefGoogle Scholar
  2. 2.
    J. A. Fiorino, J. W. Jones, and S. G. Capar,Anal. Chem. 48, 120–125 (1976).PubMedCrossRefGoogle Scholar
  3. 3.
    B. Welz and M. Melcher,Atomic Absorption Newsletter 18, 121, 122 (1979).Google Scholar
  4. 4.
    R. C. Chu, G. P. Barron, and A. W. Baumgarner,Anal. Chem. 44, 1476–1479 (1972).CrossRefGoogle Scholar
  5. 5.
    R. Blust, A. V. der Linden, and W. Decleir,Atomic Spectroscopy 6, 163–165 (1985).Google Scholar
  6. 6.
    M. M. Kimberly and D. C. Paschal,Anal. Chim. Acta 174, 203–210 (1985).CrossRefGoogle Scholar
  7. 7.
    M. Abdulla and J. Chmielnicka,Biol. Trace Elem. Res. 23, 25–53 (1990).CrossRefGoogle Scholar
  8. 8.
    S. B. Adeljou and A. M. Briggs,Anal. Chem. 57, 1386–1390 (1985).CrossRefGoogle Scholar
  9. 9.
    C. J. Menedes-Botet and M. K. Schwartz,Anal. Chem. 63, 194R-199R (1991).CrossRefGoogle Scholar
  10. 10.
    K. M. Hambldge, C. E. Casey, and N. F. Krebs,Trace Elements in Human and Animal Nutrition, 5th. ed., Academic, New York,vol. 2, Chapter 1 (1986).Google Scholar
  11. 11.
    Y. Hayashi, K. Hunakawa, N. Yoshida, M. Ishizawa, and R. Tsujino,Bunseki kagaku 25, 409 (1976).Google Scholar
  12. 12.
    R. Kobayashi and K. Imizmi,Anal. Sci. 7, 1197–1200 (1991).CrossRefGoogle Scholar
  13. 13.
    E. Berman,Toxic Metals and Their Analysis, Heyden, London (1980).Google Scholar
  14. 14.
    F. Baruthio,Biol. Trace Elem. Res. 32, 145–153 (1992).PubMedGoogle Scholar
  15. 15.
    S. Langard and T. Norseth,Handbook on the Toxicology of Metals, L. Friberg et. al., eds., Elsevier/North-Holland Biomedical, Amsterdam, pp. 383–397 (1979).Google Scholar
  16. 16.
    J. Marshall and J. M. Ottaway,Tatanta,30, 571–577 (1983).CrossRefGoogle Scholar
  17. 17.
    P. Dube,Atomic Spectroscopy 9, 55–58 (1988).Google Scholar
  18. 18.
    A. S. Prasad,Trace Elements and Iron in Human Metabolism, Plenum, New York (1978).Google Scholar
  19. 19.
    B. L. O'Dell,Med. Clin. North Amer. 60, 687–703 (1976).Google Scholar

Copyright information

© Humana Press Inc. 1997

Authors and Affiliations

  • C. J. Horng
    • 1
  • S. R. Lin
    • 1
  1. 1.School of ChemistryKaohsiung Medical CollegeKaohsiungTaiwan, R.O.C.

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