Raman spectroscopy for the determination of coating uniformity of tablets: assessment of product quality and coating pan mixing efficiency during scale-up
Research Article
Abstract
Spray coating is an important unit operation in the pharmaceutical industry. The quality, stability, safety, and performance of the final product depend largely on the amount and uniformity of coating applied. Raman spectroscopy is used to develop a multivariate quantitative model using tablets collected from different stages of coating. Subsequently, the calibration is used for the determination of coating progress in small-scale batches. The method developed is used as a process analytical technology tool to assess the desired product quality attributes in commercial scale equipment. Insight into the mixing efficiency is gained by examining intra-tablet variability using the Raman method.
Keywords
Raman Spectroscopy Coating Uniformity Process Analytical Technology Pharmaceutical Innovation Tablet Weight
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© International Society for Pharmaceutical Engineering 2006