Biological Trace Element Research

, Volume 67, Issue 1, pp 85–92 | Cite as

Alterations in serum and brain trace element levels after antidepressant treatment

Part I. Zinc
  • Gabriel Nowak
  • Małgorzata Schlegel-Zawadzka
Original Articles


We have studied the effect of chronic treatment with imipramine, citalopram and electroconvulsive shock (ECS) on serum and brain zinc levels in rats. Chronic treatment with citalopram (but not with imipramine or ECS) significantly (approx 20%) increased the serum zinc level. Chronic treatment with both drugs slightly (by approx 10%) increase the zinc level in the hippocampus and slightly decreased it in the cortex, cerebellum and basal forebrain. Calculation of the ratio hippocampus/brain region within each group demonstrated a significantly (approx 20%) higher value after treatment with either imipramine or citalopram. Moreover, chronic ECS induced a significant increase (by 30%) in the zinc level in the hippocampus and also a slight increase (by 11–15%) in the other brain regions. Thus, these different antidepressant therapies induced an elevation of the hippocampal zinc concentration, which indicates a significant role of zinc in the mechanism of antidepressant therapy.

Index entries

Antidepressant drugs ECS zinc level brain serum, rats 


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Copyright information

© Humana Press Inc.. 1999

Authors and Affiliations

  • Gabriel Nowak
    • 1
  • Małgorzata Schlegel-Zawadzka
    • 2
  1. 1.Department of Pharmacology, Institute of PharmacologyPolish Academy of SciencesKrakówPoland
  2. 2.Department of Food Chemistry and Nutrition, Collegium MedicumJagiellonian UniversityKrakówPoland

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