Biological Trace Element Research

, Volume 51, Issue 3, pp 277–283 | Cite as

Trace elements and lipid peroxidation in uremic patients on hemodialysis

  • T. H. Lin
  • J. G. Chen
  • J. M. Liaw
  • J. G. Juang
Original Articles


Trace elements and lipid peroxidation in 26 patients with chronic renal failure treated with hemodialysis and 25 healthy subjects were observed. Both plasma and erythrocyte trace elements and plasma malon dialdehyde (MDA) were examined immediately before and after hemodialysis. Increased levels of plasma Cu, MDA, and erythrocyte Pb, Mn, Zn, and a significantly decreased plasma Se, Zn and erythrocyte Se were found in patients before hemodialysis. After a single hemodialysis, erythrocyte Mn, Cu, Zn, and plasma Cu, Al, and MDA were significantly increased whereas both plasma and erythrocyte Se were lower in patients than in healthy subjects. The level of MDA was not significantly changed during the single hemodialysis. Both plasma and erythrocyte Zn levels and plasma Cu and Al were significantly higher after hemodialysis than before hemodialysis. In conclusion, levels of trace elements are altered by hemodialysis, which may increase patient susceptibility to lipid peroxidation in uremia.

Index Entries

Malondialdehyde trace elements uremic patients hemodialysis lipid peroxidation 


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Copyright information

© Humana Press Inc. 1996

Authors and Affiliations

  • T. H. Lin
    • 1
  • J. G. Chen
    • 1
  • J. M. Liaw
    • 2
  • J. G. Juang
    • 2
  1. 1.Graduate Institute of Medicine and School of Technology for Medical SciencesKaohsiung Medical CollegeKaohsiungTaiwan, R.O.C.
  2. 2.Department of NephrologyTou-Fen Miner's General HospitalMiaoli

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