Zinc and copper concentrations in serum from Spanish women during pregnancy
A cross-sectional study of serum zinc (Zn) and copper (Cu) levels in 31 healthy pregnant women and 51 healthy, nonpregnant controls living in the Mediterranean area of Granada, Spain, was performed. The subjects were divided into two groups: Group A, consisted of pregnant women in three categories according to the trimester of pregnancy, and Group B consisted of nonpregnant women acting as controls.
In pregnant women, serum Zn levels were found from 0.300-1.340 mg/L and serum Cu from 0.936-2.304 mg/L, whereas in the nonpregnant women group, the mean serum levels were 0.947 ±0.265 mg/L for Zn and 1.092 ±0.365 mg/L for Cu. Serum Zn progressively decreased with gestation. Mean Zn levels were 0.829 ±0.253, 0.846 ±0.329, and 0.620 ±0.142 mg/L, corresponding to the first, second, and third trimesters of pregnancy, respectively.
Serum Zn concentrations were significantly lower in pregnant women as compared to controls: 0.712 ±0.236 mg/L vs 0.947 ±0.265 mg/L, respectively (p < 0.05).
In contrast, Cu levels increased with period of gestation from 1.053 ±0.498 mg/L in the first trimester to 1.616 ±0.304 mg/L in the second and 1.689 ±0.344 mg/L in the third. Serum Cu levels in the second and third trimesters of pregnancy were significantly higher (p < 0.05) than those determined during the first trimester and for nonpregnant controls. Both Zn and Cu during pregnancy did not appear to be dependent on the subject’s age (p > 0.05).
Index EntriesCopper zinc pregnancy serum Spanish women gestation period
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- 3.J. R. Turnlund, Copper, inModern Nutrinon in Health and Disease, vol. 1, 8th ed., M. E. Shils, J. A. Olson and M. Shike, eds., Lea and Febiger, Philadelphia, pp. 231–241 (1994).Google Scholar
- 4.J. C. King and C. L. Keen, Zinc, inModern Nutrition in Health and Disease, vol. 1, 8th ed., M. E. Shils, J. A. Olson, and M. Shike eds., Lea and Febiger, Philadelphia, pp. 214–230 (1994).Google Scholar
- 5.G. Jia, Analysis of serum levels of selenium, zinc, and copper in 132 patients with malignant tumors,Chung. Hua. Yu. Fang. I. Hsueh. Tsa. Chich. 25, 205–207 (1991).Google Scholar
- 6.E. L. Ma and Z.M. Jiang, Ion-exchange chromatography in simultaneous determination of serum, copper and zinc levels in patients with cancer of digestive tract,Chim. Med. J. Engl.,106, 118–121 (1993).Google Scholar
- 8.D. J. Malvy, B. Burtschy, J. Arnaud, D. Sommelet, G. Leverger, L. Dostalova, and J. Drucker, Serum beta-carotene and antioxidant micronutrients in children with cancer, “Cancer in children and antioxidant micronutrients,” The French Study Group,Inst. J. Epidemiol. 22, 761–771 (1993).CrossRefGoogle Scholar
- 11.I. Yücel, F. Arpaci, A. özet, B. Döner, T. Karayilanoglu, A. Sayar, and ö. Berk, Serum copper and zinc levels and copper/zinc ratio in patients with breast cancer,Biol. Trace Element Res. 40, 31–38 (1994).Google Scholar
- 12.G. V. Vahouny, Trace elements and cardiovascular disease,Nutr. Toxicol. 1, 135–161 (1982).Google Scholar
- 13.I. I. Dementera, M. lu. Andrianova, S. L. Dzemeshkevich, A. G. Iavarovskii, and L. S. Lokslin, Changes in the content of microelements: copper, zinc and iron in the blood of patients following cardiopulmonary bypass,Anesteziol. Reanimatol. 4, 50–53 (1993).Google Scholar
- 14.V. Govindaraju, N. Prabhudev, M. Gurappa, V. S. Jawali, P. M. Chandrasekhara, and C. N. Manjunath, Zinc in rheumatic heart valves,J. Assoc. Phys. India 41, 653–654 (1993).Google Scholar
- 15.T. Magalova, A. Brtkova, A. Bederova, I. Kajaba, and I. Puchonova, Serum copper and zinc in industrial centers in Slovakia,Biol. Trace Element Res. 40, 225–235 (1994).Google Scholar
- 18.W. J. Macganity, E. B. Dawson, and A. Fogelman, Nutrition in pregnancy and lactation, inModern Nutrition in Health and Disease, vol. 1, 8th ed., M. E. Shils, J. A. Olson, and M. Shike, eds., Lea and Febiger, Philadelphia, pp. 705–726 (1994).Google Scholar
- 19.C. A. Swanson and J. C. King, Zinc and pregnancy outcome,Am. J. Clin Nutr. 4, 763–771 (1987).Google Scholar
- 20.C. L. Keen and L. S. Hurley, Zinc and reproduction: effects of deficiency on fetal and postnatal development, inZinc in Human Biology, C. F. Mills, ed., International Life Sciences Institute, London, pp. 173–182 (1989).Google Scholar
- 28.W. Wasowicz, P. Wolkamin, M. Bednarski, J. Gromadzinska, M. Sklodowska, and K. Grzybowska, Plasma trace element (Se, Zn, Cu) concentration in maternal and umbilical cord blood in Poland. Relation with birth weight gestational age, and parity,Biol. Trace Element Res. 38, 205–215 (1993).CrossRefGoogle Scholar
- 30.E. Russanov, V. Banskalieva, and S. Lyutakova, Influence of sex hormones on the subcellular distribution of copper in sheep liver,Res. Vet. Sci. 30, 233–235 (1981).Google Scholar
- 35.M. A. Jankowski, J. Y. Urin-Hare, R. B. Rucker, J. M. Rogers, and C. L. Keen, Maternal zinc deficiency, but not copper deficiency or diabetes, results in increased embryogenic cell death in the rat: implications for mechanisms underlying abnormal development,Teratology 51, 85–93 (1995).PubMedCrossRefGoogle Scholar
- 38.F. Martin-Lagos, M. Navarro-Alarcón, C. Terrés-Martos, H. López-García de la Serrana, and M. C. López-Martónez, Serum zinc levels in healthy subjects from southeastern Spain,Biol. Trace Element Res., this issue.Google Scholar
- 39.P. J. Agget and J.T. Harries, Current status of zinc in health and disease states,Arch. Dis. Child. 54, 909–917 (1979).Google Scholar
- 42.H. K. Garg, K. C. Singhal, and Z. Arshad, A study of oral zinc supplementation during pregnancy on pregnancy outcome,Indian J. Physiol. 37, 276–284 (1993).Google Scholar
- 48.M. Casanova Bellido, A. M. Moreno Vázquez, B. Ferriz Mas, M. Casanova Roman, S. Rico de Cos, and J. M. Tapia Barros, Copper in the neonatal period. Maternal-fetal relations,An. Esp. Pediatr. 44, 145–148 (1996).Google Scholar