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Biological Trace Element Research

, Volume 36, Issue 3, pp 229–241 | Cite as

Different bioavailability in humans of wheat and fish selenium as measured by blood platelet response to increased dietary Se

  • Helle M. Meltzer
  • Karen Bibow
  • Irene T. Paulsen
  • Håvard H. Mundal
  • Gunnar Norheim
  • Halvor Holm
Article

Abstract

The bioavailabilities of selenium (Se) from Se-rich fish species and Se-rich wheat were compared in a study involving 32 healthy volunteers. Initial serum Se values were 109±16 μg/L (mean±SD). For 6 wk, one group (n=11) included Se-rich bread in their diet, bringing daily average intake of Se up to 135±25 μg/d. Another group (n=11) consumed Se-rich fish daily (average Se intake: 115±31 μg/d), whereas the control group (n=10) ate their normal diet, providing 77±25 μg Se/d. Serum Se increased by 17% (P<0.01), and platelet Se increased by 30% (P<0.01) in the wheat group. Although platelet Se decreased by 11% in the fish group, no changes in serum and platelet Se in the fish or control group reached statistical significance. Glutathione peroxidase (EC 1.11.1.9; GSH-Px) activity in serum and platelets did not change during the study, nor did platelet mercury (Hg) content. Since the dietary intake of Hg, arsenium (As), and fatty acids could not satisfactorily explain the lack of response in the fish group, the results are indicative of low bioavailability of fish Se in humans. At present, wheat Se seems to be the most important factor contributing to the body stores of Se in this study population.

Index Entries

Selenium fish selenium wheat selenium bioavailability mercury arsenium humans 

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References

  1. 1.
    M. F. Robinson, H. M. Rea, G. M. Friend, R. H. D. Steward, P. C. Snow, and C. D. Thomson,Br. J. Nutr. 39, 589–600 (1978).PubMedCrossRefGoogle Scholar
  2. 2.
    G. N. Schrauzer and D. A. White,Bioorg. Chem. 8, 303–318 (1978).Google Scholar
  3. 3.
    O. A. Levander, G. Alfthan, H. Arvilommi, J. K. Huttunen, M. Kataja, P. Koivistoinen, and J. Pikkarainen,Am. J. Clin. Nutr. 37, 887–897 (1983).PubMedGoogle Scholar
  4. 4.
    C. D. Thomson, L. K. Ong, and M. F. Robinson,Am. J. Clin. Nutr. 41, 1015–1022 (1985).PubMedGoogle Scholar
  5. 5.
    X. Luo, H. Wei, C. Yang, J. Xing, X. Liu, C. Qiao, Y. Feng, J. Liu, Y. Liu, Q. Wu, X. Liu, J. Guo, B. Stoecker, J. Spallholz, and S. P. Yang,Am. J. Clin. Nutr. 42, 439–448 (1985).PubMedGoogle Scholar
  6. 6.
    G. Yang, S. Yin, R. Zhou, L. Gu, B. Yan, Y. Liu, and Y. Liu,J. Trace Elem. Electrol. Health Dis. 3, 123–130 (1989).Google Scholar
  7. 7.
    J. Clausen and S. A. Nielsen,Biol. Trace Element Res. 15, 125–138 (1988).Google Scholar
  8. 8.
    H. M. Meltzer, G. Norheim, K. Bibow, K. Myhre, and H. Holm,Europ. J. Clin. Nutr. 44, 435–446 (1990).Google Scholar
  9. 9.
    D. J. Pearson, J. P. Day, V. J. Suarez-Mendez, P. F. Miller, S. Owen, and A. Woodcock,Europ. J. Clin. Nutr. 44, 277–283 (1990).Google Scholar
  10. 10.
    J. Ringstad, B. K. Jacobsen, and Y. Thomassen,J. Trace. Elem. Electrolytes Health Dis. 1, 27–31 (1987).PubMedGoogle Scholar
  11. 11.
    C. A. Swanson, M. P. Longnecker, C. Veillon, S. M. Howe, O. A. Levander, P. R. Taylor, P. A. McAdam, C. Brown, M. J. Stampfer, and W. C. Willett,Am. J. Clin. Nutr. 52, 858–862 (1990).PubMedGoogle Scholar
  12. 12.
    G. Yang, S. Wang, R. Zhou, and S. Sun,Am. J. Clin. Nutr. 37, 872–881 (1983).PubMedGoogle Scholar
  13. 13.
    R. F. Burk,J. Nutr. 116, 1584–1586 (1986).PubMedGoogle Scholar
  14. 14.
    L. Magos and M. Webb,Critical Rev. Tox. 8, 1–43 (1980).CrossRefGoogle Scholar
  15. 15.
    A. T. Diplock, W. J. Watkins, and M. Hewison,Ann. Clin. Res. 18, 55–60 (1986).PubMedGoogle Scholar
  16. 16.
    A. Naganuma, T. Tanaka, K. Maeda, R. Matsuda, J. Tabata-Hanyu, and N. Imura,Toxicology 29, 77–86 (1983).PubMedCrossRefGoogle Scholar
  17. 17.
    G. N. Schrauzer,J. Univ. Occupational Environmental Health 9, suppl., 208–215 (1987).Google Scholar
  18. 18.
    H. W. Lane, D. C. Warren, E. Martin, and J. McCowan,Nutr. Res. 3, 805–817 (1983).CrossRefGoogle Scholar
  19. 19.
    J. Aaseth, E. Munthe, Ö. Førre, and E. Steinnes,Scand. J. Rheumatol. 7, 237–240 (1978).PubMedCrossRefGoogle Scholar
  20. 20.
    H. M. Meltzer, K. Bibow, R. Rønneberg, M. Haugen, and H. Holm, inSelenium in Biology and Medicine, A. Wendel, ed., Springer-Verlag, Heidelberg, 1989, pp. 238–241.Google Scholar
  21. 21.
    K. Bibow and H. H. Mundal,Clin. Chem. 36, 1902–1905 (1990).PubMedGoogle Scholar
  22. 22.
    G. Norheim and A. Haugen,Acta Pharmacol. et Toxicol. 59, Suppl. VIII, 610–612 (1986).Google Scholar
  23. 23.
    G. Norheim,Proc. Fifth Europ. Conf. Food Chem., Versailles, France, vol.2, 730–734 (1989).Google Scholar
  24. 24.
    D. E. Paglia, and W. N. Valentine,J. Lab. Clin. Med. 70, 158–169 (1967).PubMedGoogle Scholar
  25. 25.
    Norwegian Nutrition CouncilFood Composition Tables. Published by the Norwegian Nutrition Council, Oslo (1984).Google Scholar
  26. 26.
    J. Kiem,Biol. Trace Element Res. 15, 83–88 (1988).Google Scholar
  27. 27.
    Y. X. Wang, and J. Kiem,Biol. Trace Element Res. 15, 89–96 (1988).Google Scholar
  28. 28.
    J. Aaseth, H. Frey, E. Glattre, G. Norheim, J. Ringstad, and Y. Thomassen,Biol. Trace Element Res. 24, 147–152 (1990).Google Scholar
  29. 29.
    I. S. Palmer, N. Thiex, and O. E. Olson,Nutr. Rep. Int. 27, 249–258 (1983).Google Scholar
  30. 30.
    M. Cikrt, A. Mravcova, I. Malatova, and V. Bencko,J. Hyg. Epidemiol. Microbiol. Immunol. 32, 17–29 (1988).PubMedGoogle Scholar
  31. 31.
    C. Ip and H. Ganther,Carcinogenesis 9, 1481–1484 (1988).PubMedCrossRefGoogle Scholar
  32. 32.
    R. J. Kraus and H. E. Ganther,Biol. Trace Element Res. 20, 105–113 (1989).CrossRefGoogle Scholar
  33. 33.
    K. R. Lowry and D. H. Baker,J. Anim. Sci. 67, 959–965 (1989).PubMedGoogle Scholar
  34. 34.
    G. Lunde,The Analysis and Characterization of Trace Elements, in Particular Bromine, Selenium and Arsenic in Marine Organisms. Central Institute for Industrial Research, University of Oslo, Ph.D. Thesis (1974).Google Scholar
  35. 35.
    K. Julshamn. Personal communication. Directorate of Fisheries, Institute of Nutrition, P.O. Box 1900 Nordnes, N-5024 Bergen, Norway (1992).Google Scholar
  36. 36.
    H. E. Ganther,Selenium in Biology and Medicine. Proc. Third International Symp. Selenium Biol. Med. G. F. Combs, J. E. Spallholz, O. A. Levander, and J. E. Oldfield, eds. AVI, New York: 1987, pp. 53–65.Google Scholar
  37. 37.
    D. T. Tsay, A. W. Halverson, and I. S. Palmer,Nutr. Reports Int. 2, 203–207 (1970).Google Scholar
  38. 38.
    H. Vokal-Borek,Selenium. University of Stockholm, Institute of Physics, November 1979. USIP Report 79-16 (1979).Google Scholar
  39. 39.
    M. Janghorbani, R. F. Martin, L. J. Kasper, X. F. Sun, and V. R. Young,Am. J. Clin. Nutr. 51, 670–677 (1990).PubMedGoogle Scholar
  40. 40.
    M. Thorngren and B. Åkesson,Internat. J. Vit. Nutr. Res. 57, 429–435 (1987).Google Scholar
  41. 41.
    M. F. Robinson, H. M. Rea, G. M. Friend, R. H. D. Steward, P. C. Snow, and C. D. Thomson,Br. J. Nutr. 39, 589–600 (1978).PubMedCrossRefGoogle Scholar
  42. 42.
    R. Bach, U. Schmidt, F. Jung, H. Kiesewetter, B. Hennen, E. Wenzel, H. Schieffer, L. Bette, and S. Heyden,Ann. Nutr. Metabol. 33, 359–367 (1989).CrossRefGoogle Scholar
  43. 43.
    A. Bjørneboe, A. K. Smith, G.-E. Aa. Bjørneboe, P. O. Thune, and C. A. Drevon,Br. J. Dermatology 118, 77–83 (1988).CrossRefGoogle Scholar
  44. 44.
    K. Bibow,Dietary Intake and Bioavailability of Trace Elements, Especially Selenium. Ph.D. thesis, Department of Chemistry, University of Oslo, Norway (1991).Google Scholar
  45. 45.
    H. M. Meltzer, G. Norheim, E. B. Løken, and H. Holm,Br. J. Nutr. 67, 287–294 (1992).PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1993

Authors and Affiliations

  • Helle M. Meltzer
    • 1
  • Karen Bibow
    • 2
  • Irene T. Paulsen
    • 1
  • Håvard H. Mundal
    • 3
  • Gunnar Norheim
    • 4
  • Halvor Holm
    • 1
  1. 1.Institute for Nutrition Research University of OsloOsloNorway
  2. 2.Department of ChemistryUniversity of OsloOsloNorway
  3. 3.Department of Internal MedicineUllevål HospitalOsloNorway
  4. 4.Department of Pharmacology and ToxicologyNorwegian College of Veterinary Medicine/National Veterinary InstituteOsloNorway

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