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Gastroenterologia Japonica

, Volume 26, Issue 4, pp 465–471 | Cite as

Hepatic collagen synthesis in patients with alcoholic and nonalcoholic liver disease

  • Yoshikazu Murawaki
  • Sciichi Kato
  • Chisato Hirayama
Liver, Pancreas and Biliary Tract

Summary

To examine the synthesis of hepatic collagen in patients with alcoholic and nonalcoholic liver disease, liver biopsy specimens were incubated in vitro with14C-proline, and the radioactivity of the newly synthesized protein-bound14C-hydroxyproline was measured. Mean hepatic collagen synthesis was 0.82±0.19 pmole of14C-hydroxyproline/g liver/2 h in control subjects without histological liver fibrosis. Hepatic collagen synthesis was increased in patients with alcoholic and nonalcoholic liver diseases, especially in those with alcoholic fibrosis, alcoholic cirrhosis and chronic active hepatitis. The raised collagen synthesis in alcoholic liver disease rapidly decreased after withdrawal of alcohol. When alcoholic liver disease were compared with nonalcoholic liver disease, there was no significant difference in hepatic collagen synthesis.

Key words

alcoholic liver disease hepatic collagen synthesis nonalcoholic liver disease 

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Copyright information

© The Japanese Society of Gastroenterology 1991

Authors and Affiliations

  • Yoshikazu Murawaki
    • 1
  • Sciichi Kato
    • 1
  • Chisato Hirayama
    • 1
  1. 1.Second Department of Internal MedicineTottori University School of MedicineYonagoJapan

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