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Gastroenterologia Japonica

, Volume 12, Issue 3, pp 224–229 | Cite as

Experimental study on transductal dissemination of cancer of the pancreas

  • Nobuhiro Fujita
  • Akira Nakase
Original Article

Summary

Experimental studies on the mechanism of transductal dissemination of the pancreas carcinoma was made in rabbit by injection of Vx2 carcinoma suspension into the pancreatic duct. Ductal occlusion was conductive to nidation and growth in the pancreas of intraductal floating cancer cells, but tumor growth also occurred in 40% of animals in which the duct was not occluded.

The mechanisms of nidation in the pancreas of intraductal floating cancer cells were direct embedding into the ductal wall, and leakage of cancer cells from the duct in the process of pancreatic fibrosis due to ductal obstruction.

Expansive tumor growth in the pancreas was more vigorous the smaller the degree of fibrosis of the pancreas, and was most active where associated acute pancreatitis was seen or where the pancreas was X-irradiated one week before injection of carcinoma suspension.

Key Words

VX2 carcinoma transductal dissemination of pancreatic cancer nidation and growth of intraductal cancer cells in the pancreas 

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References

  1. 1).
    Collins JJ, Jr, Craighead JE, Brooks JR: Rationale for total pancreatectomy for carcinoma of the pancreatic head. New Eng J Med 274: 599, 1966CrossRefPubMedGoogle Scholar
  2. 2).
    Hicks RE, Brooks JR: Total pancreatectomy for ductal carcinoma. Surg Gynec & Obstet 133: 16, 1971Google Scholar
  3. 3).
    Rosen RG, Garret M, Aka E: Cytologie diagnosis of pancreatic cancer by ductal aspiration. Ann Surg 167: 427, 1968CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© The Japanese Society of Gastroenterology 1977

Authors and Affiliations

  • Nobuhiro Fujita
    • 1
  • Akira Nakase
    • 1
  1. 1.First Department of SurgeryKyoto University Medical SchoolSakyo-ku, KyotoJapan

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