Biological Trace Element Research

, Volume 63, Issue 2, pp 167–175

Age-dependent changes in metallothionein levels in liver and kidney of the Japanese

  • Minoru Yoshida
  • Hisayoshi Ohta
  • Youji Yamaguchi
  • Yukio Seki
  • Morihisa Sagi
  • Kentarou Yamazaki
  • Yawara Sumi
Article

Abstract

Samples of liver, renal cortex, and medulla were obtained from 55 forensic autopsies (0- to 95-yr-old Japanese). Metallothionein (MT) was determined by the Ag-hem or Cd-hem method. Zinc (Zn), copper (Cu), and cadmium (Cd) were determined by atomic absorption spectrophotometry. The mean levels of MT were 250 μg/g in the liver, and 394 μg/g (cortex) and 191 μg/g (medulla) in the kidney. Age-dependent changes were observed in both the liver and kidney. In the liver, MT level decreased during infancy and increased thereafter with age. Similar age-dependent changes in the levels of Zn and Cu were observed. In the kidney cortex, MT level increased with age, although no correlation was found after middle age. The levels of Cd and Zn also increased with age until middle age; however, they decreased thereafter. These results suggest that age-dependent changes in renal MT levels are associated with accumulation of Cd.

Index Entries

Metallothionein cadmium zinc copper liver kidney human Japanese 

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Copyright information

© Humana Press Inc. 1998

Authors and Affiliations

  • Minoru Yoshida
    • 1
  • Hisayoshi Ohta
    • 2
  • Youji Yamaguchi
    • 2
  • Yukio Seki
    • 2
  • Morihisa Sagi
    • 3
  • Kentarou Yamazaki
    • 3
  • Yawara Sumi
    • 1
  1. 1.Department of ChemistrySt. Marianna University School of MedicineKawasakiJapan
  2. 2.Department of Occupational Health and Toxicology, School of Allied Health ScienceKitasato UniversitySagamiharaJapan
  3. 3.Department of Legal MedicineSt. Marianna University School of MedicineKawasakiJapan

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