Endocrine

, Volume 7, Issue 1, pp 73–76

Functional consequences of the somatopause and its treatment

  • Andrew R. Hoffman
  • Steven A. Lieberman
  • Gail Butterfield
  • Janice Thompson
  • Raymond L. Hintz
  • Gian Paolo Ceda
  • Robert Marcus
Symposium on the Assessment of the Growth Hormone/IGF-I Axis in Aging

Abstract

The decline in the function of the growth hormone-releasing hormone, growth hormone, insulin-like growth factor (GHRH-GH-IGF) axis has been termed the somatopause. Many of the catabolic sequelae seen in normal aging has been attributed to this decrease in circulating GH and IGF-I. In order to provide hormone replacement therapy for the somatopause, elderly subjects have been treated with GH, IGF-I, or both hormones together. Whereas numerous beneficial effects on body composition, strength, and quality of life have been reported in some studies, other studies have reported only marginal functional imporvements. Moreover, it is clear that both hormones can cause significant morbidity.

Key Words

GH IGF-I somatopause body composition 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Humana Press Inc 1997

Authors and Affiliations

  • Andrew R. Hoffman
    • 1
    • 2
  • Steven A. Lieberman
    • 1
    • 2
  • Gail Butterfield
    • 1
    • 2
  • Janice Thompson
    • 1
    • 2
  • Raymond L. Hintz
    • 1
    • 2
  • Gian Paolo Ceda
    • 1
    • 2
  • Robert Marcus
    • 1
    • 2
  1. 1.GRECC and Medical ServiceVA Palo Alto Health Care SystemPalo Alto
  2. 2.Departments of Medicine and PediatricsStanford University School of MedicinePalo Alto
  3. 3.Medical Service (111)VA Medical CenterPalo Alto

Personalised recommendations