Advertisement

Gastroenterologia Japonica

, Volume 10, Issue 1, pp 29–34 | Cite as

Studies on the etiology of milk intolerance in Japanese adults

  • Yutaka Yoshida
  • Giro Sasaki
  • Shohei Goto
  • Shigetoshi Yanagiya
  • Kazuo Takashina
Original Article

Summary

  1. 1.

    The incidence of milk intolerance is approximately 19% in Japanese adults when 200 ml of milk is given. However, a much greater incidence was assumed when considered under the criteria of Western standard.

     
  2. 2.

    The lactase activity was significantly greater in milk drinkers than non-drinkers. And, internation ally, the activity is higher in those nationalities whose milk consumption is greater.

     
  3. 3.

    Lactase is an adaptive enzyme and rather easily induced by lactose load feeding in animals. From the data of our own and of the literature, it was further confirmed that environmental factors play a more important role than genetic factors in the etio-pathogenesis of milk intolerance.

     

Key words

milk intolerance primary adult hypolactasia disaccharidase lactase lactose load feeding 
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1).
    Durand, P.: Lactosuria idiopathica in una paziente con diarrea cronica ed acidosi. Minerva Pediat., 10: 706–711, 1958.PubMedGoogle Scholar
  2. 2).
    Holzel, A. et al.: Defective lactose absorption causing malabsorption in infancy. Lancet, 1 : 1126–1128, 1959.PubMedCrossRefGoogle Scholar
  3. 3).
    Ferguson, A. and Maxwell, J.D.: Genetic aetiology of lactose intolerance. Lancet, 2: 188–190, 1967.PubMedCrossRefGoogle Scholar
  4. 4).
    Dahlqvist, A. et al.: Intestinal lactase deficiency and lactose intolerance in adults. Gastroenterology., 45: 488–491, 1963.PubMedGoogle Scholar
  5. 5).
    Haemmerli, U.P. et al.: Lactasemangel der Dunndarmmucosa als Ursache gewisser Formen erworbener Milchintoleranz beim Erwachsenen. Hael. Med. Acta., 30: 693–705, 1963.Google Scholar
  6. 6).
    Chung, M.H. and McGill, D.B.: Lactase deficiency in Orientals. Gastroenterogy., 54: 225–226, 1968.Google Scholar
  7. 7).
    Bolin, T.D. et al.: Lactose intolerance in Singapore. Gastroenterology., 59: 76–84, 1970.PubMedGoogle Scholar
  8. 8).
    Sasakawa, T. and Ogoshi, K.: Studies on lactase deficiency (lactose intolerance) in adults. Diag. and Treat., 58: 1009–1017, 1970 (Japanese).Google Scholar
  9. 9).
    Ueda, H. et al. : Milk Intolerance in Japanese. J.Jap. Med., No. 2360: 13–18, 1969 (Japanese).Google Scholar
  10. 10).
    Inoue, M. et al.: Lactase deficiency. Therapy, 51: 559–567, 1969 (Japanese).Google Scholar
  11. 11).
    Namiki, M. and Naka, K.: Milk intolerance in Ainu tribe. Jap. J. Gastroenterology, 69: 421, 1972 (Japanese).Google Scholar
  12. 12).
    Sasaki, G.: Intestinal lactase activity in Japanese adults. Jap. J. Gastroentetology, 68: 37–49, 1971 (Japanese).Google Scholar
  13. 13).
    “Sumposium on Milk Intolerance” at the 13th Annual Autumnal Meeting (1971) of The Japanese Society of Gastroenterology. Jap. J. Gastroenterology, 69: 414–424,1972 (Japanese).Google Scholar
  14. 14).
    Newcomer, A.D. and McGill, D.B.: Disaccharidase activity in the small intestine, prevalence of lactase deficinecy in 100 healthy subjects. Gastroenterology., 53: 881–889, 1967.PubMedGoogle Scholar
  15. 15).
    Bayless, T.M. and Rosensweig, N.S.: A racial difference in incidence of lactase deficiency. JAMA, 197: 968–972, 1966.PubMedCrossRefGoogle Scholar
  16. 16).
    Welsh, J.D. et al.: Studies of lactose intolerance in families. Arch. Intern. Med. (Chicago), 122: 315–317, 1968.Google Scholar
  17. 17).
    Cuatrecasea, P. et al.: Lactase deficiency in the adult. A common occurrence. Lancet, 1: 14–18, 1965.CrossRefGoogle Scholar
  18. 18).
    Desai, H.G. et al.: Intestinal disaccharidases in tropical sprue. Gastroenterology., 53: 375–380, 1967.PubMedGoogle Scholar
  19. 19).
    Dahlqvist, A.: Method for assay of intestinal disaccharidases. Anal. Biochem., 7: 18–25, 1964.PubMedCrossRefGoogle Scholar
  20. 20).
    Lowry, O.H. et al.: Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265–275, 1951.PubMedGoogle Scholar
  21. 21).
    Sheehy, T.W. and Anderson, P.R.: Disaccharidase activity in normal and disease small bowel. Lancet, 7401–7404, 1965.Google Scholar
  22. 22).
    Economic Yearbook of Dairy Firm. Dairy Economic News Agency, Tokyo, 1974 (Japanese).Google Scholar
  23. 23).
    Creamer, B.: The Small Intestine. Heinemann Medical Books LTD, London, 1974.Google Scholar
  24. 24).
    Matsunaga, F.: Lactase deficiency. J. Clin. Science, 4: 1000–1003, 1968 (Japanese).Google Scholar
  25. 25).
    Yoshida, Y.: Jejunal disaccharidase activity. Jap. J. Gastroent., 66: 499–450, 1969 (Japanese).Google Scholar
  26. 26).
    Goto, S.: Disaccharidase activity in the jejunal mucosa. Jap. J. Int. Med., 62: 747–755, 1973 (Japanese).Google Scholar
  27. 27).
    Yoshida, Y. et al.: Lactose intolerance in Japanese adults. The 9th International Congress of Gastroenterology (Paris), 1972.Google Scholar
  28. 28).
    Shibuya, Y. et al.: Lactose tolerance in Japanese. Igaku No Ayumi, 72: 323–324, 1970 (Japanese).Google Scholar
  29. 29).
    Haemmerli, U.P, et al.: Acquired milk intolerance in the adult caused by lactose malabsorption due to a selective deficiency of intestinal lactase activity. American Jounal of Medicine, 38: 7–30, 1965.CrossRefGoogle Scholar

Copyright information

© The Japanese Society of Gastroenterology 1975

Authors and Affiliations

  • Yutaka Yoshida
    • 1
    • 2
  • Giro Sasaki
    • 1
  • Shohei Goto
    • 1
  • Shigetoshi Yanagiya
    • 1
  • Kazuo Takashina
    • 1
  1. 1.First Department of Internal MedicineHirosaki University School of MedicineJapan
  2. 2.1st Department of Internal MedicineHirosaki University School of MedicineHirosaki CityJapan

Personalised recommendations

Cite article

Buy options