Gastroenterologia Japonica

, Volume 27, Issue 1, pp 23–28 | Cite as

Expression of MHC class II antigens (HLA-DR, -DP, and -DQ) on human gastric epithelium

  • Nobuaki Ishii
  • Mitsuro Chiba
  • Masahiro Iizuka
  • Hiroyuki Watanabe
  • Tomonori Ishioka
  • Osamu Masamune
Alimentary Tract


Class II antigen expression on gastric epithelium was investigated using an immunoperoxidase method in relation to the degree of inflammatory cell infiltration in the lamina propria. Sixty-six biopsy specimens from 43 patients with chronic gastritis were examined. The frequency of HLA-DR expression in specimens with cell infiltration was 94%, while that in specimens without cell infiltration was 24%. There was significant difference in the frequency of HLA-DR expression between the two groups (P<0.01). HLA DR fwas most intensely expressed in the glandular neck portion. The frequency and extent of class II antigen expression on gastric epithelium with cell infiltration were in the following order: DR>DP>DQ. The extent of DR and DP, but not DQ expression generally paralleled the degree of cell infiltration. Intestinal metaplasia was found in 13 specimens. In the area of intestinal metaplasia, epithelial class II staining was absent except for one specimen. These results suggest that the respectivegenes of three class II antigens are regulated by different mechanisms and that an immunological mechanism plays a role in the pathogenesis of gastritis.

Key words

class II antigens gastric epithelium HLA-DR HLA-DP HLA-DQ 


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Copyright information

© The Japanese Society of Gastroenterology 1992

Authors and Affiliations

  • Nobuaki Ishii
    • 1
  • Mitsuro Chiba
    • 1
  • Masahiro Iizuka
    • 1
  • Hiroyuki Watanabe
    • 1
  • Tomonori Ishioka
    • 1
  • Osamu Masamune
    • 1
  1. 1.First Department of Internal MedicineAkita University School of MedicineAkitaJapan

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