, Volume 26, Issue 3, pp 178–180

Whipple’s disease with aortic regurgitation requiring aortic valve replacement

  • T. Schneider
  • M. Salamon-Looijen
  • A. von Herbay
  • H. Schwerdt
  • S. Weg-Remers
  • A. Stallmach
  • M. Zeitz
Case Report


Cardiac involvement in Whipple’s disease is well established. However, clinical consequences beside antibiotic therapy have rarely been reported. Our observation of a middle-aged man with increasing dyspnea, fatigue, chest pain, and dizziness leading to admission to a cardiology department demonstrates that cardiac symptoms may represent the main symptoms in patients with Whipple’s disease. The diagnosis was not made prior to upper endoscopy, performed because of diarrhea, and revealed Whipple’s agent now classified asTropheryma whippelii, which is a PAS-positive rod-shaped bacterium in the macrophages of the intestinal lamina propria. The aortic valve was replaced after the intestinal symptoms were resolved by antibiotic treatment reducing the number of infectious agents in the duodenal mucosa. Histological analysis of the aortic valve demonstrated the presence of PAS-positive rod shaped material as the most likely cause of aortic insufficiency. Five months after valve replacement, the patient had completely recovered from intestinal and cardiac symptoms. Still under antibiotic treatment 16 months later, no more PAS-positive macrophages were detectable in the intestinal mucosa.


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Copyright information

© MMV Medizin Verlag GmbH München 1998

Authors and Affiliations

  • T. Schneider
    • 1
  • M. Salamon-Looijen
    • 2
  • A. von Herbay
    • 3
  • H. Schwerdt
    • 4
  • S. Weg-Remers
    • 1
  • A. Stallmach
    • 1
  • M. Zeitz
    • 1
  1. 1.Medzinische Klinik IIUniversitätsklinik Homburg/SaarHomburg/SaarGermany
  2. 2.Pathologisches InstitutUniversitätsklinikHomburg/SaarGermany
  3. 3.Pathologisches InstitutUniversitätsklinik HeidelbergGermany
  4. 4.Medizinische Klinik IIIUniversitätsklinikHomburg/SaarGermany

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