, Volume 26, Issue 1, pp 48–53 | Cite as

Does aggregation substance ofEnterococcus faecalis contribute to development of endocarditis?

  • M. Berti
  • G. Candiani
  • A. Kaufhold
  • A. Muscholl
  • R. Wirth
Experimental Study Originalia


Aggregation substance (AS) ofEnterococcus faecalis which is encoded by socalled sex pheromone plasmids enables the bacteria to bind toin vitro-cultured pig kidney tubular cells. It is reported that the presence of AS is not of pivotal importance for the ability ofE. faecalis to cause infective endocarditis (EN). The lines of evidence for this are two-fold: 1) sex pheromone plasmids and, therefore, the gene for AS were not present more often in epidemiologically unrelated strains ofE. faecalis isolated from human cases of EN than in isolates from well-water (26 vs. 18%); 2) the presence of the adhesin did not correlate with the establishment of EN in an animal (rat) model. The data are discussed with respect to the specificity of interaction of AS with eukaryotic cells and the results of other studies.


Endocarditis Infective Endocarditis Enterococcus Faecalis Western Blot Experiment Plasmid Transfer 
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Copyright information

© MMV Medizin Verlag GmbH München 1998

Authors and Affiliations

  • M. Berti
    • 1
  • G. Candiani
    • 1
  • A. Kaufhold
    • 2
  • A. Muscholl
    • 3
  • R. Wirth
    • 3
  1. 1.Lepetit Research CenterMedical Microbiology Dept.GerenzanoItaly
  2. 2.SmithKline Beecham BiologicalsRixensartBelgium
  3. 3.LS Mikrobiologie-NWF IIIUniversität RegensburgRegensburgGermany

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