, Volume 26, Issue 2, pp 126–130 | Cite as

Experimental genital tract infection withChlamydia psittaci (GPIC agent) in male rats

  • C. A. Jantos
  • J. Augustin
  • B. Durchfeld-Meyer
  • W. Baumgärtner
  • H. G. Schiefer
Experimental Studies Originalia


The course of experimental chlamydial infection of the male genital tract was studied. Inoculation of theChlamydia psittaci agent of guinea pig inclusion conjunctivitis (GPIC agent) into the vas deferens of rats resulted in chlamydial infection of the epididymis, testis and the prostate gland. The inflammatory response was most prominent at 14 days after infection. Chlamydiae were recovered from the epididymides and the prostate glands for up to 90 and 60 days post inoculation, respectively. Histopathological changes associated with chlamydial infection of the epididymis or prostate gland were characterized by intratubular and interstitial purulent inflammation. Chlamydia-specific IgM- and IgG-antibodies were found in sera of nearly all infected animals. Results of this study indicate that this animal model may be useful to study the pathogenesis, immune responses and sequelae of chlamydial infections of the male genital tract.


Genital Tract Prostatitis Prostate Gland Chlamydial Infection Trachoma 
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© MMV Medizin Verlag GmbH Mönchen 1998

Authors and Affiliations

  • C. A. Jantos
    • 1
  • J. Augustin
    • 1
  • B. Durchfeld-Meyer
    • 3
  • W. Baumgärtner
    • 2
  • H. G. Schiefer
    • 1
  1. 1.Institut für Medizinische MikrobiologieKlinikum der Justus-Liebig-Universität GiessenGiessen
  2. 2.Institut für Veterinär-PathologieJustus-Liebig-Universität GiessenFrankfurtGermany
  3. 3.Präklinische Entwicklung Arzneimittelsicherheit PathologieHoechst Marion Roussel DeutschlandFrankfurtGermany

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