International Urology and Nephrology

, Volume 26, Issue 5, pp 535–540

Cytomegalovirus prostatitis

Case report and review of the literature
  • T. C. McKay
  • D. M. Albala
  • K. Sendelbach
  • P. Gattuso


We report the case of a patient undergoing chemotherapy for multiple myeloma discovered to have cytomegalovirus prostatitis. The findings of a hypoechoic prostatic lesion on ultrasound and a slightly elevated prostatic specific antigen of 4.6 ng/ml prompted a prostate biopsy. Cytopathologic examination and immunohistochemical staining demonstrated cytomegalovirus within the prostate. This virus is a common pathogen in the immunosuppressed patient, but its presence in the male genital tract is relatively rare. No previous reports of biopsy-proven cytomegalovirus prostatitis appear in the literature. The relationship of cytomegalovirus to the prostate is discussed in detail.


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  1. 1.
    Ho, M.: Epidemiology of cytomegalovirus infections.Rev. Infect. Dis. (Suppl. 7),12, 701 (1990).Google Scholar
  2. 2.
    Benson, P. J., Smith, C. S.: Cytomegalovirus prostatitis.Urology, 40, 165 (1992).PubMedCrossRefGoogle Scholar
  3. 3.
    Lang, D. J., Kummer, J. F., Harley, D. P.: Cytomegalovirus in semen.N. Engl. J. Med., 291, 121 (1974).PubMedCrossRefGoogle Scholar
  4. 4.
    Handsfield, H. H., Chandler, S. H., Caine, V. A., Meyers, J. D., Corey, L., Medeiros, E., McDougall, J. K.: Cytomegalovirus infection in sex partners: Evidence for sexual transmission.J. Infect. Dis., 151, 344 (1985).PubMedGoogle Scholar
  5. 5.
    Rook, A. H.: Interactions of cytomegalovirus with the human immune system.Rev. Infect. Dis. (Suppl. 3),10, 460 (1988).Google Scholar
  6. 6.
    Ho, M.: Cytomegalovirus: Biology and Infection, 2nd ed. Plenum Publishing Co., New York 1991, pp. 293–297.Google Scholar
  7. 7.
    McCarthy, J. M., McLoughlin, M. G., Shackleton, C. R., Cameron, E. C., Yeung, C. K., Jones, E. C., Keown, P. A.: Cytomegalovirus epididymitis following renal transplantation.J. Urol., 146, 417 (1991).PubMedGoogle Scholar
  8. 8.
    Randazzo, R. F., Hulette, C. M., Gottlied, M. S., Rajfer, J.: Cytomegalovirus epididymitis in a patient with the acquired immune deficiency syndrome.J. Urol., 136, 1095 (1986)PubMedGoogle Scholar
  9. 9.
    Mayo, D., Armstrong, J. A., Ho, M.: Activation of latent murin cytomegalovirus infection: Cocultivation, cell transfer, and the effect on immunosuppression.J. Infect. Dis., 138, 890 (1978).PubMedGoogle Scholar
  10. 10.
    Chou, S.: Acquisition of donor strains of cytomegalovirus by renal transplant recipients.N. Engl. J. Med., 314, 1418 (1986).PubMedCrossRefGoogle Scholar
  11. 11.
    Niedt, G. W., Schirella, R. A.: Acquired immunodeficiency syndrome: Clinicopathologic study of 568 autopsies.Arch. Pathol. Lab. Med., 109, 727 (1985).PubMedGoogle Scholar
  12. 12.
    Michaelson, R. A., Benson, G. S., Friedman, H. M.: Urinary retention as the presenting symptom of acquired cytomegalovirus infection.Am. J. Med., 74, 526 (1983).PubMedCrossRefGoogle Scholar
  13. 13.
    Shinohara, K., Scardino, P. T., Carter, S. S., Wheeler, T. M.: Pathologic basis of the sonographic appearance of the normal and malignant prostate.Urol. Clin. North. Am., 16, 675 (1989).PubMedGoogle Scholar
  14. 14.
    Doble, A., Carter, S. S.: Ultrasonographic findings in prostatitis.Urol. Clin. North. Am., 16, 771 (1989).Google Scholar
  15. 15.
    Laychock, A. M., Geder, L., Sanford, E. J., Rapp, F.: Immune response of prostatic cancer patients to cytomegalovirus-infected and transformed human cells.Cancer, 42, 1766 (1978).PubMedCrossRefGoogle Scholar
  16. 16.
    Boldogh, I., Baskar, J. F., Mar, E., Huang, E.: Human cytomegalovirus and herpes simplex type 2 in normal and adenocarcinomatous prostate glands.J. Natl. Cancer Inst., 70, 819 (1983).PubMedGoogle Scholar

Copyright information

© Akadémiai Kiadó 1994

Authors and Affiliations

  • T. C. McKay
    • 1
  • D. M. Albala
    • 1
  • K. Sendelbach
    • 2
  • P. Gattuso
    • 2
  1. 1.Department of UrologyLoyola University Medical CenterMaywoodUSA
  2. 2.Department of PathologyLoyola University Medical CenterMaywoodUSA

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