Molecular Biology

, Volume 34, Issue 4, pp 449–460 | Cite as

Gene networks

  • N. A. Kolchanov
  • E. A. Anan’ko
  • F. A. Kolpakov
  • O. A. Podkolodnaya
  • E. V. Ignat’eva
  • T. N. Goryachkovskaya
  • I. L. Stepanenko
Article
Received:

Abstract

Gene network is a group of genes functioning in a coordinated manner to control vital processes in an organism. Each gene network includes several essential components: (1) a group of genes which form a core of a gene network, (2) proteins encoded by these genes, (3) signal transduction pathways, (4) negative and positive feedback which provide for autoregulation, and (5) low-molecular-weight compounds. To accumulate the information on gene networks, a database GeneNet has been developed (http://wwwmgs.bionet.nsc.ru/systems/mgl/genet/). At present, GeneNet contains the data on 16 gene networks which are arranged in six sections according to the subject concerned: lipid metabolism, steroidogenesis, erythropoiesis, antiviral response, plant seed development, and heat shock. Analysis of these data revealed the following principles of the gene network organization: (1) there is a great variety of molecular mechanisms which provide for a feedback regulation; (2) each gene network includes key genes which coordinate the function of the other genes of the gene network; (3) one transcription factor activates many genes via a cassette mechanism; and (4) gene networks are autoregulated via regulatory circuits with positive and negative feedback.

Key words

genes expression regulation gene networks databases signal transduction pathways 
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Copyright information

© MAIK “Nauka/Interperiodica” 2000

Authors and Affiliations

  • N. A. Kolchanov
    • 1
  • E. A. Anan’ko
    • 1
  • F. A. Kolpakov
    • 1
  • O. A. Podkolodnaya
    • 1
  • E. V. Ignat’eva
    • 1
  • T. N. Goryachkovskaya
    • 1
  • I. L. Stepanenko
    • 1
  1. 1.Institute of Cytology and Genetics, Siberian DivisionRussian Academy of SciencesNovosibirskRussia

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