Chinese Journal of Clinical Oncology

, Volume 1, Issue 2, pp 90–95 | Cite as

Association of body mass index with risk of lung cancer: Evidence from a middle -aged male cohort in Shanghai, China

Original Article
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Accepted:

Abstract

Objective

To investigate the relationship between body mass index (BMI) and lung cancer risk among men in urban Shanghai, China.

Methods

Between January 1, 1986 and September 30, 1989, a total of 18,244 male residents of urban Shanghai were recruited in the prospective cohort study. The eligible study subjects were those aged 45 to 64 years and without history of cancer. Through July 10th, 2003 (17 years follow-up), 467 new cases of lung cancer were identified in the cohort. Cox regression models were used to estimate the adjusted relative risks (RRs) and 95% confidence intervals (Cls).

Results

The risk of lung cancer decreased with increasing in BMI. After adjustment for some potential confounding factors, a relative risk of 0.6 (highest versus lowest quintile of BMI) was observed (P-trend =0.01). Stratified by smoking status, an inverse association of body mass index with lung cancer risk still existed among current smokers. There were too few cases of lung cancer to draw a valid result among men who never smoked. The results also showed that the association of BMI with the risk of lung adenocarcinoma was more apparent than with other histological subtypes.

Conclusion

An inverse association of BMI with lung cancer risk may exist among men in Shanghai.

Key words

prospective cohort study lung cancer body mass index male 
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References

  1. 1.
    Kabat GC, Wynder EL. Body mass index and lung cancer risk. Am J Eidemiol. 1992; 135:769–774.Google Scholar
  2. 2.
    Goodman MT, Wilkens LR. Relation of body size and the risk of lung cancer. Nutr Cancer. 1993; 20: 179–186.PubMedCrossRefGoogle Scholar
  3. 3.
    Nomura A, Heilbrun LK, Stemmermann GN. Body mass index as a predictor of cancer in men. J Nail Cancer Inst. 1985; 74:319–323.Google Scholar
  4. 4.
    Choyou PH, Nomura AM, Stemmermann GN. A prospective study of weight, body mass index and other anthropometric measurements in relation to site-specific cancers. Int J Cancer. 1994; 57: 313–317.CrossRefGoogle Scholar
  5. 5.
    Knekt P, Heliovaara M, Rissanen A, et al. Leanness and lung cancer risk. Int J Cancer. 1991; 49: 208–213.PubMedCrossRefGoogle Scholar
  6. 6.
    Olson JE, Yang P, Schmitz K, et al. Differential association of body mass index and fat distribution with three major histologic types of lung cancer: Evidence from a cohort of older women. Am J Epidemiol. 2002; 156: 606–615.PubMedCrossRefGoogle Scholar
  7. 7.
    Rauscher GH, Mayne ST, Janerich DT. Relation between body mass index and lung cancer risk in men and women never and former smokers. Am J Epidemiol. 2000; 152: 506–513.PubMedCrossRefGoogle Scholar
  8. 8.
    Drinkard CR, Sellers TA, Potter JD, et al. Association of body mass index and body fat distribution with risk of lung cancer in older women. Am J Epidemiol. 1995; 142:600–607.PubMedGoogle Scholar
  9. 9.
    Xiang YB, Gao YT, Zhong LJ, et al. A case-control study on relationship between body mass index and lung cancer in non-smoking women. Chin J Prev Med. 1999;33:9–12.Google Scholar
  10. 10.
    Gao YT. Risk factors for lung cancer among nonsmokers with emphasis on lifestyle factors. Tumor. 1996;16:498–501.Google Scholar
  11. 11.
    Du YX, Zha Q, Chen XW, et al. Epidemiologic studies on risk factors for lung cancer in Guangzhou. Tumor. 1996;16: 492–497Google Scholar
  12. 12.
    Wack JT, Rodin J. Smoking and its effects on body weight and the systems of caloric regulation. Am J Clin Nutr. 1982; 35:366–380.PubMedGoogle Scholar
  13. 13.
    Rigotti NA. Cigarette smoking and body weight. N Engl J Med. 1989;320:931–933.PubMedCrossRefGoogle Scholar
  14. 14.
    Perkins KA, Epstein LH, Marks BL, et al. The effect of nicotine on energy expenditure during light physical activity. N Engl J Med. 1989;320:898–903.PubMedCrossRefGoogle Scholar
  15. 15.
    Blot WJ, Fraumeni JF Jr. Cancers of the lung and pleura. In: Schottenfeld D, Fraumeni JF Jr, eds. Cancer epidemiology and prevention. New York, NY: Oxford University Press. 1996; 637–665.Google Scholar
  16. 16.
    Devesa SS, Shaw GL, Blot WJ. Changing patterns of lung cancer incidence by histological type. Cancer Epidemiol Biomarkers Prev. 1991; 1:29–134.PubMedGoogle Scholar
  17. 17.
    Preston-Martin S, Pike MC, Ross RK, et al. Increased cell division as a cause of human cancer. Cancer Res. 1990; 50: 7415–7421.PubMedGoogle Scholar
  18. 18.
    Garn SM, Rosenberg KR, Schaefer AE. Relationship between fatness level and size attainment in Central America. Ecol Food Nutr. 1983; 13:157–165.CrossRefGoogle Scholar

Copyright information

© Chinese Anti-Cancer Association and Springer 2004

Authors and Affiliations

  • Enju Liu
    • 1
  • Xueli Wang
    • 1
  • Jianmin Yuan
    • 2
  • Yutang Gao
    • 1
  1. 1.Deptment of EpidemiologyCancer Institute of Shanghai Jiaotong University and Shanghai Cancer InstituteShanghaiChina
  2. 2.University of Southern CaliforniaUSA

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