Russian Journal of Bioorganic Chemistry

, Volume 26, Issue 5, pp 317–321 | Cite as

Proteolytic specificity of plasmin toward adhesive proteins

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Abstract

We showed that plasmin specifically hydrolyzes proteins participating in cell adhesion (fibronectin, vitronectin, and laminin) and does not affect nonadhesive proteins, such as albumin, ovalbumin, and alkaline phosphatase. These and some earlier results allow us to speak of the specific antiadhesive activity of plasmin, which significantly extends the concepts regarding the functional importance of this protein and indicates that it directly participates in the regulation of cell adhesion, the remodeling of the extracellular matrix, and, therefore, in cell migration.

Key words

plasmin cell adhesion fibronectin vitronectin laminin 

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References

  1. 1.
    Ingber, D.E.,J. Cell Sci., 1993, vol. 104, pp. 613–627.PubMedGoogle Scholar
  2. 2.
    Juliano, R.L. and Haskill, S.,J. Cell Biol., 1993, vol. 120, pp. 577–585.PubMedCrossRefGoogle Scholar
  3. 3.
    Sims, J.R., Karp, S., and Ingber, D.E.,J. Cell Sci., 1992, vol. 103, pp. 1215–1222.PubMedGoogle Scholar
  4. 4.
    Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., and Watson, J.D.,Molecular Biology of the Cell, New York: Garland, 1983. Translated under the titleMolekulyarnaya biologiya kletki, Moscow: Mir, 1994, vol. 2, pp. 522–529.Google Scholar
  5. 5.
    Mignatti, P. and Rifkin, D.B.,Physiol. Rev., 1993, vol. 73, pp. 161–195.PubMedGoogle Scholar
  6. 6.
    Moscatelli, D. and Rifkin, D.B.,Biochim. Biophys. Acta, 1988, vol. 948, pp. 67–85.PubMedGoogle Scholar
  7. 7.
    Eaton, D.L., Scott, R.W., and Baker, J.B.,J. Biol. Chem., 1984, vol. 259, pp. 6241–6247.PubMedGoogle Scholar
  8. 8.
    Matrisian, L.M.,BioEssays, 1992, vol. 14, pp. 455–463.PubMedCrossRefGoogle Scholar
  9. 9.
    Werb, Z.,Cell, 1997, vol. 91, pp. 439–442.PubMedCrossRefGoogle Scholar
  10. 10.
    Wong, A.P., Contez, Sh.L., and Baricos, W.H.,Am. J. Physiol., 1992, vol. 263, pp. F1112-F1118.PubMedGoogle Scholar
  11. 11.
    Muranova, T., Shvyrkova, I., Arkhipov, V., and Rykunova, A.,Fibrinolysis Proteolysis, 1998, vol. 12, pp. 23–32.CrossRefGoogle Scholar
  12. 12.
    Muranova, T.A., Shvyrkova, I.G., and Rykunova, A.I.,Bioorg. Khim., 1999, vol. 26, pp. 187–191.Google Scholar
  13. 13.
    Deutch, D.G. and Mertz, E.T.,Science, 1970, vol. 170, pp. 1095–1096.CrossRefGoogle Scholar
  14. 14.
    Alkjaersig, N., Fletcher, A.P., and Sherry, S.,J. Biol. Chem., 1958, vol. 233, pp. 81–85.PubMedGoogle Scholar
  15. 15.
    Dufour, S., Duband, J.-L., and Thiery, J.-P.,Biol. Cell, 1986, vol. 58, pp. 1–14.PubMedGoogle Scholar
  16. 16.
    Regnault, V., Rivat, C., and Stolz, J.F.,J. Chromatogr., 1988, vol. 432, pp. 93–102.PubMedCrossRefGoogle Scholar
  17. 17.
    Skorstengaard, K., Thogersen, H.C., Vibe-Pedersen, K., Petersen, T.E., and Magnusson, S.,Eur. J. Biochem., 1982, vol. 128, pp. 605–623.PubMedCrossRefGoogle Scholar
  18. 18.
    McDonagh, R.P., McDonagh, J., Petersen, T.E., Thogersen, H.C., Skorstengaard, K., Sottrup-Jensen, L., and Magnusson, S.,FEBS Lett., 1981, vol. 127, pp. 174–178.PubMedCrossRefGoogle Scholar
  19. 19.
    Thogersen, H.C., Petersen, T.E., Skorstengaard, K., Vibe-Pedersen, K., McDonagh, R., McDonagh, J., Magnusson, S., and Sottrup-Jensen, L., Abstracts of Papers,Protides Biological Fluids, Brussels, 1980, Abstr. no. 28.Google Scholar
  20. 20.
    Gold, L.I., Schwimmer, R., and Quigley, J.P.,Biochem. J., 1989, vol. 262, pp. 529–534.PubMedGoogle Scholar
  21. 21.
    Yatohgo, T., Izumi, M., Kashiwagi, H., and Hayashi, M.,Cell Struct. Funct., 1988, vol. 13, pp. 281–292.PubMedCrossRefGoogle Scholar
  22. 22.
    Kost, Ch., Benner, K., Stockmann, A., Linder, D., and Preissner, K.T.,Eur. J. Biochem., 1996, vol. 236, pp. 682–688.PubMedCrossRefGoogle Scholar
  23. 23.
    Luckenbill-Edds, L.,Brain Res. Rev., 1997, vol. 23, pp. 1–27.PubMedCrossRefGoogle Scholar
  24. 24.
    Preissner, K.T.,Biophys. Biochem. Res. Commun., 1990, vol. 168, pp. 966–971.CrossRefGoogle Scholar
  25. 25.
    Knudsen, B.S., Silverstein, R.L., Leung, L.L.K., Harpel, P.C., and Nachman, R.L.,J. Biol. Chem., 1986, vol. 261, pp. 10765–10771.PubMedGoogle Scholar
  26. 26.
    Silverstein, R.L., Leung, L.L.K., Harpel, P.C., and Nachman, R.L.,J. Clin. Invest., 1985, vol. 75, pp. 2065–2073.PubMedCrossRefGoogle Scholar
  27. 27.
    Salonen, E.M., Saksela, O., Vartio, T., Nielson, L.S., and Zeuthen, J.,J. Biol. Chem., 1985, vol. 260, pp. 12 302–12 307.Google Scholar
  28. 28.
    Lawler, J.W. and Slayter, H.S.,Thrombosis Research, 1981, vol. 22, pp. 267–279.PubMedCrossRefGoogle Scholar
  29. 29.
    Hamilton, K.K., Fretto, L.J., Griersa, D.S., and McKee, P.A.,J. Clin. Invest., 1985, vol. 76, pp. 261–270.PubMedGoogle Scholar
  30. 30.
    Liotta, L.A., Goldfarb, R.H., Brundage, R., Siegal, G.P., Terranova, V., and Garbisa, S.,Cancer Res., 1981, vol. 41, pp. 4629–4636.PubMedGoogle Scholar
  31. 31.
    Sane, D.C., Moser, T.L., and Greenberg, C.S.,Thrombosis Haemostasis, 1991, vol. 66, pp. 310–314.Google Scholar
  32. 32.
    Chain, D., Kreizman, T., Shapira, H., and Shaltid, S.,FEBS Lett., 1991, vol. 285, pp. 251–256.PubMedCrossRefGoogle Scholar
  33. 33.
    Affinity Chromatography: Principles and Methods, Pharmacia Fine Chemicals, 1979, pp. 10–15.Google Scholar
  34. 34.
    Walther, P.J., Steinman, H.M., Hill, R.M., and McKee, P.A.,J. Biol. Chem., 1974, vol. 249, pp. 1173–1181.PubMedGoogle Scholar
  35. 35.
    Osterman, L.A.,Khromatografiya belkov i nukleinovykh kislot (Chromatography of Proteins and Nucleic Acids), Moscow: Nauka, 1985, pp. 348–349.Google Scholar
  36. 36.
    Fujkawa, K., Thompson, A.R., Legaz, M.E., Meyer, R.G., and Davie, E.W.,Biochemistry, 1973, vol. 12, pp. 4938–4945.CrossRefGoogle Scholar
  37. 37.
    Bradford, M.M.,Anal. Biochem., 1976, vol. 72, pp. 248–254.PubMedCrossRefGoogle Scholar
  38. 38.
    Laemmly, U.K.,Nature, 1970, vol. 227, pp. 680–685.CrossRefGoogle Scholar

Copyright information

© MAIK “Nauka/Interperiodica” 2000

Authors and Affiliations

  1. 1.Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch)Russian Academy of SciencesPushchino, Moscow oblastRussia

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