Russian Journal of Bioorganic Chemistry

, Volume 26, Issue 5, pp 317–321

Proteolytic specificity of plasmin toward adhesive proteins


DOI: 10.1007/BF02759283

Cite this article as:
Shvyrkova, I.G. & Muranova, T.A. Russ J Bioorg Chem (2000) 26: 317. doi:10.1007/BF02759283


We showed that plasmin specifically hydrolyzes proteins participating in cell adhesion (fibronectin, vitronectin, and laminin) and does not affect nonadhesive proteins, such as albumin, ovalbumin, and alkaline phosphatase. These and some earlier results allow us to speak of the specific antiadhesive activity of plasmin, which significantly extends the concepts regarding the functional importance of this protein and indicates that it directly participates in the regulation of cell adhesion, the remodeling of the extracellular matrix, and, therefore, in cell migration.

Key words

plasmin cell adhesion fibronectin vitronectin laminin 

Copyright information

© MAIK “Nauka/Interperiodica” 2000

Authors and Affiliations

  1. 1.Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch)Russian Academy of SciencesPushchino, Moscow oblastRussia

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