Russian Journal of Bioorganic Chemistry

, Volume 26, Issue 6, pp 419–422 | Cite as

The synthesis and antioxidant activity of azole derivatives of hemin

  • E. A. Rozhkova
  • A. I. Lysko
  • K. V. Kuleshov
  • R. P. Evstigneeva
Article
Received:
Revised:

Abstract

New derivatives of proto- and deuterohemin IX containing tri- and tetrazole rings were synthesized and characterized. A pronounced antioxidant activity was found for these compounds in the Fe(II)/ascorbate-dependent system of lipid peroxidation in murine liver homogenates.

Key words

hemin azoles synthesis antioxidant activity lipid peroxidation liver homogenates 

Abbreviations

HOBt

1-hydroxybenzotriazole

LPO

lipid peroxidation

MDA

malondialdehyde

NTB

Nitrotetrazolium Blue

P-Fe

ferric porphyrinate

TPP

tetraphenylporphyrin

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Copyright information

© MAIK “Nauka/Interperiodica” 2000

Authors and Affiliations

  • E. A. Rozhkova
    • 1
  • A. I. Lysko
    • 2
  • K. V. Kuleshov
    • 1
  • R. P. Evstigneeva
    • 1
  1. 1.Lomonosov State Academy of Fine Chemical TechnologyMoscowRussia
  2. 2.Research Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia

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