The Indian Journal of Pediatrics

, Volume 65, Issue 2, pp 283–289

Maternal substance abuse

Symposium: Advances in Neonatology—II

Abstract

The epidemic of substance abuse, which has swept through much of the world, has len behind a trail of devastated lives and families. Alcohol and substance abuse by women during pregnancy has also been reported to be widespread and can affect the unborn fetus with the potential for life-long disabilities. While the magnitude of the perinatal substance abuse has been the focus of much discussion in the West, the problem is greatly underestimated in other parts of the world. In this article, the author has focused on five highly-abused substances and explored the effects of the drugs on the fetus and the newborn. There is a constant need for evaluating the epidemiology and the consequences of perinatal substance abuse so that health programs can target measures to eliminate the preventable morbidity that results from this practice.

Key words

Substance abuse Fetus Disabilities 

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References

  1. 1.
    Ray I. Drug, delinquency and doctor (editorial).J India Med Assoc 1994; 92: 74–75.Google Scholar
  2. 2.
    U.S. Department of Health and Human Services, National Household Survey on Drug Abuse. 1994.Google Scholar
  3. 3.
    Chasnoff IJ, Landress HJ, Barrett M. The prevalence of illicit drug or alcohol use during pregnancy and discrepancies in mandatory reporting in Pinellas Country Florida.N Eng J Med 1990; 322: 1202–1206.CrossRefGoogle Scholar
  4. 4.
    Poshyachinda V. Drug injecting and HIV infection among the population of drug abusers in Asia.Bull Narcotics 1993; 45: 77–89.Google Scholar
  5. 5.
    Sarkar S, Das N, Panda Set al. Rapid spread in HIV among injecting drug abusers in northeastern states in India.Bull Narcotics 1993; 45: 91–105.Google Scholar
  6. 6.
    Jones KL, Smith DW. Recognition of fetal alcohol syndrome in early infancy.Lancet 1073; 2: 999–1001.Google Scholar
  7. 7.
    Jeret JS. Fetal alcohol syndrome.JAMA 1991; 226: 1077.Google Scholar
  8. 8.
    Jones KL. Fetal alcohol syndrome.Pediatric in Review, 1986; 4: 122–126.CrossRefGoogle Scholar
  9. 9.
    Spohr HL, Willms J, Steinhausen HC. Prenatal alcohol exposure and long-term developmental consequences.Lancet 1993; 341: 907–910.PubMedCrossRefGoogle Scholar
  10. 10.
    Streissguth AP, Asae JM, Clarren SKet al. Fetal alcohol syndrome in adolescents and adults.JAMA 1991; 265: 1961–1967.PubMedCrossRefGoogle Scholar
  11. 11.
    Blackard C, Tennes K. Human placental transfer of cannabinoids.N Engl J Med 1984; 311: 797.PubMedGoogle Scholar
  12. 12.
    Perez RM, Wall ME. Presence of Δ-9 tetrahydrococannabinol in human milk.N. Engl J Med 1982; 307: 819–829.CrossRefGoogle Scholar
  13. 13.
    Hutchings DE, Morgan B, Brake SCet al. Delta-9 tetrahydrocannabinol during pregnancy in the rat: I. Differential effects on maternal nutrition, embryo toxicity and growth in the offspring.Neurotoxicol Teratol 1987; 9: 39–43.PubMedCrossRefGoogle Scholar
  14. 14.
    Fried PA, Watkinson B, Dillon RDet al. Neonatal neurological status in a low-risk population after prenatal exposure to cigarettes, marijuana, and alcohol.J Dev Behav Pediatr 1987; 8: 318–326.PubMedCrossRefGoogle Scholar
  15. 15.
    Zuckerman B, Frank DA, Hingson Ret al. Effects of maternal marijuana and cocaine use of fetal growth.N Engl J Med 1989; 320: 762–769.PubMedCrossRefGoogle Scholar
  16. 16.
    Fried PA. Marijuana use during pregnancy. Consequences for the offspring.Seminars in Perinatology 1991; 15: 280–287.PubMedGoogle Scholar
  17. 17.
    Hatch EE, Bracken MB. Effect of marijuana use in pregnancy of fetal growth.Am J Epidemiology 1986; 124: 986–993.Google Scholar
  18. 18.
    Fried PA. Prenatal exposure to tobacco and marijuana: effects during pregnancy, infancy, and early childhood.Clinical Obstetr Gynecol 1993; 36: 319–337.CrossRefGoogle Scholar
  19. 19.
    Fried PA, O'Connel CM, Watkinson B. 60 and 72 months follow-up of children prenatally exposed to marijuana, cigarettes, and alcohol: cognitive and language assessment.J Dev Behav Ped 1992; 13: 383.Google Scholar
  20. 20.
    Kain AN, Rimar S, Barash PG. Cocaine abuse in the parturient and effects on the fetus and neonate.Anesth Analg 1993; 77: 835–845.PubMedCrossRefGoogle Scholar
  21. 21.
    Jain L, Meyer W, Moore Cet al. Detection of fetal cocaine exposure by analysis of amniotic fluid.Abstet Gynecol 1993; 81: 787–790.Google Scholar
  22. 22.
    Chasnoff IJ, Burns WJ, Schneel SHet al. Cocaine use in pregnancy.N Engl J Med 1985; 313: 666–669.PubMedCrossRefGoogle Scholar
  23. 23.
    Ryan L, Ehrlich S, Finnegan L. Cocaine abuse in pregnancy: effect on the fetus and the newborn.Neurotoxicol Teratol 1987; 9: 295–299.PubMedCrossRefGoogle Scholar
  24. 24.
    Bell GL, Lau K. Perinatal and neonatal issues of substance abuse.Pediatr Clin N Amer 1995; 42: 261–281.Google Scholar
  25. 25.
    Chasnoff IJ, Burns KA, Burns WJ. Cocaine use in pregnancy: perinatal morbidity and mortality.Neurotoxicol Teratol 1987; 9: 292–293.CrossRefGoogle Scholar
  26. 26.
    Chasnoff IJ, Bussey ME, Santch Ret al. Perinatal cerebral infarction and maternal cocaine use.J Pediatr 1986; 018: 455–459.Google Scholar
  27. 27.
    Abel EL. Smoking during pregnancy: a review of effects on growth and development of offspring.Hum Biol 1980; 52: 593–625.PubMedGoogle Scholar
  28. 28.
    Czeizel AE, Kodaj I, Lenz W. Smoking during pregnancy and congenital limb deficiency.BMJ 1994; 308: 1473–1476.PubMedGoogle Scholar
  29. 29.
    Cotton P. Smoking cigarettes may do developing fetus more harm than ingesting cocaine, some experts say.JAMA 1994; 271: 576–577.PubMedCrossRefGoogle Scholar
  30. 30.
    Rosen TS, Johnson HL. Children of methadone maintained mothers: follow-up to 18 months of age.J Pediatr 1982; 101: 192–196.PubMedCrossRefGoogle Scholar
  31. 31.
    Naeye RL, Blanc W, Leblanc Wet al. Fetal complications of maternal heroin addicition: abnormal growth, infections and episodes of stress.J Pediatr 1973; 83: 1055–1061.PubMedCrossRefGoogle Scholar
  32. 32.
    Pruitt AW, Anyan WR, Hill RMet al. Neonatal drug withdrawal.Pediatrics 1983; 72: 985–902.Google Scholar
  33. 33.
    Ting S, Jain L, Fadavi S, Punwani I, Vidyasagar D. Abnormal feeding behaviour in drug-exposed infants.Pediatr Res 1992; 31: 14A.Google Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 1998

Authors and Affiliations

  1. 1.Emory University School of MedicineAtlantaUSA

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