Advertisement

Acta diabetologia latina

, Volume 24, Issue 2, pp 157–162 | Cite as

Evaluation of central nervous conduction by visual evoked potentials in insulin-dependent diabetic children. metabolic and clinical correlations

  • Giancarlo Comi
  • Vittorio Martinelli
  • Giuseppe Galardi
  • Stefania Medaglini
  • Luciano Beccaria
  • Franco Meschi
  • Luca Rosti
  • Nadia Bressani
  • Giuseppe Chiumello
Original Contributions

Summary

Peripheral neuropathy is a well-known complication of diabetes, but few data are available on central lesions. Visual evoked potentials (VEPs) seem a reliable and feasible technique for detecting a conduction delay in the central nervous, system. Seventy-one insulin-dependent type 1 diabetic children (mean age 15±3 years) and 33 controls were investigated for central neuropathy. We used a pattern of reversal stimulation with television display of a checker board pattern (15 min and 30 min check size). The latencies of the positive peak (P100 wave) were significantly lengthened in 17 patients (27%) but no correlation was found between VEPs and age, duration of diabetes, insulin requirement and HbA1 level. A negative correlation was found between VEPs and peripheral nervous conduction velocity. VEPs measurement seems a simple and reliable technique for detecting early alterations in CNS function in diabetics. Our data suggest that central and peripheral nervous alterations progress simultaneously.

Key-words

Diabetic complications Type I diabetes Visual evoked potentials 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Canal N., Comi G., Saibene V., Musca B., Pozza G: Relationship between peripheral and autonomic neuropathy in insulin-dependent diabetes: a clinical and instrumental evaluation. In:Canal N., Pozza G, (Eds): Peripheral neuropathies. Elsevier, North Holland Biomedical Press, Amsterdam, 1978; p. 247–253.Google Scholar
  2. 2.
    Cirillo D., Gonfiantini E., DeGrandis D., Bongiovanni L., Robert J.J., Pinelli L.: Visual evoked potentials in diabetic children and adolescents.—Diabetes Care7, 273–275, 1984.PubMedCrossRefGoogle Scholar
  3. 3.
    Comi G., Locatelli T., Ghilardi M.F., Medaglini S., Martinelli V., Mandelli A.: Median and tibial somatosensory evoked potentials in diabetes mellitus. In: Evoked potentials neurophysiological and clinical aspects.Morocutti C., Rizzo P. A. (Eds.): Elsevier Science Publishers B.V. (Biomedical Division), Amsterdam 1985;p. 233–237.Google Scholar
  4. 4.
    De Jong R. N.: CNS manifestations of diabetes mellitus.—Postgrad. Med.6, 101–107, 1977.Google Scholar
  5. 5.
    Donald M. W., Bird C. E., Lawson J. S., Letemendia, F. J. J., Monga T. N., Surridge D. H. C., Varette-Cerre P., Williams D. M. L., Williams D. L., Wilson D. L.: Delayed auditory brainstem responses in diabetes mellitus—J. Neurol. Neurosurg. Psychiat.44, 641–644, 1981.PubMedGoogle Scholar
  6. 6.
    Donald M. W., Williams Erdahl D. L., Surridge D. H. C., Monga T. N., Lawson J. S., Bird C. E., Letemendia F. J. J.: Functional correlates of reduced central conduction velocity in diabetic subjects—Diabetes33, 627–633, 1984.PubMedCrossRefGoogle Scholar
  7. 7.
    Fichsel N.: Visually evoked potentials in diabetic children. In:Laron Z. (Ed.): Pediatric adolescent endocrinology. Vol. 2. Basel, Karger, 1977; p. 182–187.Google Scholar
  8. 8.
    Franceschi, M., Truci G., Comi G., Lozza L., Marchettini P., Galardi G., Smirne S.: Cognitive deficits and their relationship to other neurological, complications in chronic alcoholic patients.—J. Neurol. Neurosurg. Psychiat.47, 1134–1137, 1984.PubMedGoogle Scholar
  9. 9.
    Kontoc C., Costas, C., Stamboulis E., Siafakas A., Papageargiov C.: Changes in the blink reflex and visual evoked potentials in patients with diabetes mellitus.—Electroencephalogr. clin. Neurophysiol.61, S188, 1985.Google Scholar
  10. 10.
    Papacostopoulos D., Hart J. C. D., Harney J., Rowland J., Corall R.: Combined electrophysiological assessment of the visual system in insulin dependent diabetics—Electroencephalogr. clin. Neurophysiol.61, S187, 1985.Google Scholar
  11. 11.
    Puvanedran K., Devathasan G., Wong, P. K.: Visual evoked responses in diabetes.—J. Neurol. Neurosurg. Psychiatr.46, 643–647, 1983.CrossRefGoogle Scholar
  12. 12.
    Reske Nielsen E., Lundbaeck K.: Pathological changes in the central and peripheral nervous system of young long-term diabetics. The spinal cord and peripheral nerves—Diabetologia4, 34–43, 1968.PubMedCrossRefGoogle Scholar

Copyright information

© Casa Editrice «il Ponte» 1987

Authors and Affiliations

  • Giancarlo Comi
    • 1
  • Vittorio Martinelli
    • 1
  • Giuseppe Galardi
    • 1
  • Stefania Medaglini
    • 2
  • Luciano Beccaria
    • 2
  • Franco Meschi
    • 2
  • Luca Rosti
    • 2
  • Nadia Bressani
    • 2
  • Giuseppe Chiumello
    • 2
  1. 1.Clinical Neurologica, VUniversità degli Studi di Milano, Istituto Scientifico H San RaffaeleMilanoItaly
  2. 2.Clinica Pediatrica III Centro di Endocrinologia Infantile e dell'AdolescenzaUniversità degli Studi di Milano, Istituto Scientifico H San Raffaele

Personalised recommendations