Molecular Neurobiology

, Volume 10, Issue 2–3, pp 75–89

Genetic mechanisms of early neurogenesis inDrosophila melanogaster

  • Jose A. Campos-Ortega
Proceedings of the Satellite of the 14th ISN Meeting and the First International Workshop entitled The Neuronal Phenotype Molecular Biology, Cell Specification, and Therapeutic Frontiers held in Lozari, Corsica, France, August 19–20, 1993

DOI: 10.1007/BF02740668

Cite this article as:
Campos-Ortega, J.A. Mol Neurobiol (1995) 10: 75. doi:10.1007/BF02740668


The neurogenic ectoderm ofDrosophila melanogaster consists of the ventral neuroectoderm and the procephalic neuroectoderm. It is hypothesized that epidermal and central neural progenitor cells separate from each other in three steps: conference on the neuroectodermal cells the capability of producing neural or epidermal progenies, separation of the two classes of progenitor cells, and specification of particular types of neuroblasts and epidermoblasts. Separation of neuroblasts and epidermoblasts in controlled by proneural and neurogenic genes.Delta andNotch serve as mediators of direct protein-protein interactions. E(spl)-C inhibits neurogenesis, creating epidermal cells. The achaete-scute complex (AS-C) controls the commitment of nonoverlapping populations of neuroblasts and leads the development of neuroectodermal cells as neuroblasts.

Index Entries

Drosophila melanogaster Delta Notch E(spl)-C AS-C 


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Copyright information

© Humana Press Inc 1995

Authors and Affiliations

  • Jose A. Campos-Ortega
    • 1
  1. 1.Institut für EntwicklungsbiologieUniversität zu KölnKölnGermany

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