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Molecular Neurobiology

, Volume 14, Issue 1–2, pp 19–35 | Cite as

The effects of interferon-γ on the central nervous system

  • Brian Popko
  • Joshua G. Corbin
  • Kristine D. Baerwald
  • Jeffrey Dupree
  • Annie M. Garcia
Article

Abstract

Interferon-gamma (IFN-γ) is a pleotropic cytokine released by T-lymphocytes and natural killer cells. Normally, these cells do not traverse the blood-brain barrier at appreciable levels and, as such, IFN-γ is generally undetectable within the central nervous system (CNS). Nevertheless, in response to CNS infections, as well as during certain disorders in which the CNS is affected, T-cell traffic across the blood-brain barrier increases considerably, thereby exposing neuronal and glial cells to the potent effects of IFN-γ. A large portion of this article is devoted to the substantial circumstantial and experimental evidence that suggests that IFN-γ plays an important role in the pathogenesis of the demyelinating disorder multiple sclerosis (MS) and its animal model experimental allergic encephalomyelitis (EAE). Moreover, the biochemical and physiological effects of IFN-γ are discussed in the context of the potential consequences of such activities on the developing and mature nervous systems.

Index Entries

Cytokines demyelination neural development 

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Copyright information

© Humana Press Inc 1997

Authors and Affiliations

  • Brian Popko
    • 1
    • 2
    • 3
  • Joshua G. Corbin
    • 1
  • Kristine D. Baerwald
    • 1
  • Jeffrey Dupree
    • 1
  • Annie M. Garcia
    • 1
  1. 1.Curriculum in Neurobiology UNC Neuroscience CenterUniversity of North CarolinaChapel Hill
  2. 2.Department of Biochemistry and Biophysics UNC Neuroscience CenterUniversity of North CarolinaChapel Hill
  3. 3.Program in Molecular Biology and Biotechnology UNC Neuroscience CenterUniversity of North CarolinaChapel Hill

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