Endocrine Pathology

, Volume 10, Issue 4, pp 299–304

Focal and diffuse beta cell changes in persistent hyperinsulinemic hypoglycemia of infancy

  • Günter Klöppel
  • Axel Reinecke-Lüthge
  • Frank Koschoreck
Clinical Research


In recent years our understanding of the changes in the endocrine pancreas in persistent hyperinsulinemic hypoglycemia in infancy, a form of congenital hypoglycemia, has increased considerably, in terms of both morphological classification and molecular pathogenesis. This review summarizes the current state of knowledge about the pathological lesions in the pancreas and their relationship to recently reported molecular findings.

Key Words

Persistent hyperinsulinemic hypoglycemia in infancy endocrine pancreas molecular changes 


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Copyright information

© Humana Press Inc 1999

Authors and Affiliations

  • Günter Klöppel
    • 1
  • Axel Reinecke-Lüthge
    • 1
  • Frank Koschoreck
    • 1
  1. 1.Department of PathologyUniversity of KielKielGermany

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