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Endocrine

, Volume 6, Issue 2, pp 187–194 | Cite as

Role of interleukin-1β, interleukin-6, and TNF-α in intestinal maturation induced by dietary spermine in rats

  • Mohammadi Kaouass
  • Patricia Deloyer
  • Isabelle Gouders
  • Olivier Peulen
  • Guy Dandrifosse
Original Articles

Abstract

In the present investigation, the authors aimed to evaluate the role of cytokines in intestinal postnatal maturation induced by dietary polyamines. Neonatal rats were administered either saline or spermine (8 μmol) orally. Spermine increased interleukin-1β (IL-1β), IL-6, and TNF-α plasma concentration. The maximum concentrations of IL-1β, IL-6, and TNF-α were, respectively, observed at 4, 4, and 8 h posttreatment. Intraperitoneal (ip) injection of IL-1β increased the specific activity of sucrase in whole small intestine, whereas the specific activities of maltase and lactase were significantly enhanced only in the jejunum. IL-6 elicited sucrase and increased maltase specific activity in the whole small intestine, but lactase specific activity was not affected. TNF-α had no effect on sucrase and maltase specific activity, but a slight augmentation of lactase specific activity was detected in the jejunum. Spermine and spermidine content in the intestine was increased by ip injection of IL-1β and IL-6. Corticosterone secretion was elevated by single ip injection of IL-1β, IL-6, or TNF-α. These findings suggest that spermine could induce postnatal intestinal development and corticosterone secretion through a cytokine-dependent mechanism.

Key Words

Spermine cytokines corticosterone intestine suckling rats 

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Copyright information

© Humana Press Inc 1997

Authors and Affiliations

  • Mohammadi Kaouass
    • 1
  • Patricia Deloyer
    • 1
  • Isabelle Gouders
    • 1
  • Olivier Peulen
    • 1
  • Guy Dandrifosse
    • 1
  1. 1.Department of Biochemistry and General Physiology, Institute of ChemistryUniversity of LiegeLiegeBelgium

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