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Pancreatic neuroendocrine carcinoma metastatic to the breast as part of the multiple endocrine neoplasia type 1 syndrome

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Abstract

Breast metastases from nonmammary tumors are rare. We report here the first case of pancreatic neuroendocrine carcinoma metastatic to the breast in a patient with possible multiple endocrine neoplasia type 1. The diagnosis was supported by histological examination, immunohistochemistry, and ultrastructural analysis. This observation emphasizes the importance of clinical data for an accurate diagnosis, especially during intraoperative examination. When pathologists are faced with an unusual breast tumor larger than 2 cm, we would recommend freezing and/or saving pieces of tissue for ultrastructural analysis, which might help in the diagnosis.

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Authors and Affiliations

  1. Unité d’Oncologie Médicale, Centre Hospitalier Lyon Sud, Jules Courmont-Saint Eugénie, Pierre-Bénite, France

    Gilles Freyer MD

  2. Département de Chirurgie Carcinologique, Centre Léon Bérard, Lyon, France

    Alain Brémond MD

  3. Département d’Anatomie et de Cytologie Pathologiques, Centre Léon Bérard, 28 rue Laënnec, 69373, Lyon Cédex 08, France

    Isabelle Treilleux MD, PhD, Gilles Freyer MD, Eric Tabone PhD, Catherine Chassagne-Clément MD & Christiane Bailly MD

Authors
  1. Isabelle Treilleux MD, PhD
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  2. Gilles Freyer MD
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  3. Eric Tabone PhD
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  4. Catherine Chassagne-Clément MD
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  5. Alain Brémond MD
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  6. Christiane Bailly MD
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Correspondence to Isabelle Treilleux MD, PhD.

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Treilleux, I., Freyer, G., Tabone, E. et al. Pancreatic neuroendocrine carcinoma metastatic to the breast as part of the multiple endocrine neoplasia type 1 syndrome. Endocr Pathol 8, 251–258 (1997). https://doi.org/10.1007/BF02738793

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