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Cell Biochemistry and Biophysics

, Volume 31, Issue 3, pp 321–329 | Cite as

β-adrenergic receptor desensitization in cardiac hypertrophy and heart failure

  • Dong-Ju Choi
  • Howard A. RockmanEmail author
Article

Conclusion

Based on our recent data (37,54,56) and the association that profound alterations in βAR signaling are found in chronic end-stage human heart failure (64), it is possible that defects in this pathway are primary elements that underlie the transition from compensated to decompensated cardiac failure. Decreasing the level of myocardial βARK1 in established heart failure, is a novel approach to improving impaired βAR receptor function and potentially alter the pathogenesis in this disease.

Keywords

Carvedilol Cardiac Hypertrophy Cell Biochemistry Biophysics Volume Adenylyl Cyclase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press, Inc 1999

Authors and Affiliations

  1. 1.Department of MedicineUniversity of North Carolina at Chapel HillChapel Hill
  2. 2.Department of Medicine and Cardiovascular Research InstituteGyeong-Sang National UniversityChinjuKorea

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