Integrative Physiological & Behavioral Science

, Volume 39, Issue 2, pp 126–138

Effects of a carbohydrate supplement upon resting brain activity

  • Chenghua Wang
  • Joanne S. Szabo
  • Roscoe A. Dykman
Papers

Abstract

Glucose is a major energy source for the brain, and along with several monosaccharide derivatives as components of brain gangliosides, they play important roles in neurologic function. However, there is little information available on the role of glucose and other monosaccharides on resting brain activity. This study was designed to evaluate the effects of a single dose of a carbohydrate supplement containing glucose and several of its derivatives on resting brain activity in 20 healthy male college students. The supplement provided an insignificant amount of carbohydrate (3.9 g), protein (0.28 g), fat (0 g), and calories (14 kcal). The amount of glucose in the supplement was 0.5 g (1% the amount of glucose used in adult studies of cognitive functioning and memory). We hypothesized that the glyconutrient supplement would enhance brain activity associated with alertness and attention. The study design was double blind, with subjects randomly assigned to one of two orders, either carbohydrate supplement week one followed by placebo a week later, or the opposite. Electrical brain activity was monitored by 15 electrodes positioned at nine standard international 10–20 system locations, including three bilateral pairs at frontal, parietal, and occipital sites. Thirty minutes following ingestion of a placebo or carbohydrate supplement drink, EEG activity was recorded for 10-mins while subjects focused on a stationary visual target. Spectral power of resting brain activity was computed and analyzed contrasting the placebo and supplement groups. Relative to placebo, the carbohydrate supplement significantly enhanced power in three brain wave frequencies (theta, alpha, and beta) that are known to be associated with attention and arousal. Since changes were observed in the supplement but not placebo group, our study suggests that additional sugars in the glyconutritional supplement facilitate enhancement of brain electrical activity. Whether the apparent enhancement of arousal in baseline recordings is associated with improved task performance remains to be determined.

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References

  1. Alexander, J. E., O’Boyle, M.W. & Benbow, C.P. (1996). Developmentally advanced EEG alpha power in gifted male and female adolescents.International Journal of Psychophysiology, 23: 25–31.PubMedCrossRefGoogle Scholar
  2. Allen, J.B., Gross, A.M., Aloia, M.S., & Billingsley, C. (1996). The effects of glucose on nonmemory cognitive functioning in the elderly.Neuropsychologia, 34, 459–465.PubMedCrossRefGoogle Scholar
  3. Alton, G., Kjaergaard, S., Etchison, J.R., Skovby, F., & Freeze, H.H. (1997). Oral ingestion of mannose elevates blood mannose levels: a first step toward a potential therapy for carbohydrate-deficient glycoprotein syndrome type I.Biochemical Molecular Medicine, 60, 127–133.CrossRefGoogle Scholar
  4. Alton, G., Hasilik, M., Niehues, R., Panneerselvan, K., Etchison, J.R., Fana, F. & Freeze, H.H. (1998). Direct utilization of mannose for mammalian glycoprotein biosynthesis.Glycobiology, 8, 285–295.PubMedCrossRefGoogle Scholar
  5. Anderson, J.W. (1998). Nutritional management of diabetes mellitus. In: Modern Nutrition in Health and Disease (Shills, M.E., Olsen, J.A., Shike, M. & Ross A.C., eds.), pp. 1365.–1394, Lippincott.Google Scholar
  6. Andreassi, J.L. (2000). Psychophysiology, 4th ed. Lawrence Erlbaum Associates Publishers, Mahwah, New Jersey, pp 12–41.Google Scholar
  7. Benton, D. & Owens, D.S. (1993). Blood glucose and human memory.Psychopharmacology, 113, 83–88.PubMedCrossRefGoogle Scholar
  8. Benton, D. & Parker, P.Y. (1998). Breakfast, blood glucose, and cognition.American Journal of Clinical Nutrition, 67, 772S-778S.PubMedGoogle Scholar
  9. Berger, V., Perier, S., Pachiaudi, C., Normand, S., Louisot, P., & Martin, A. (1998). Dietary specific sugars for serum protein enzymatic glycosylation in man.Metabolism, 47, 1499–1503.PubMedCrossRefGoogle Scholar
  10. Bihler, I. (1969). Intestinal sugar transport: ionic activation and chemical specificity.Biochimica et Biophysica Acta, 183, 169–181.PubMedCrossRefGoogle Scholar
  11. Brunngraber, E.G., Brown, B.D. & Aro, A. (1975). Distribution and age-dependent concentration in brain tissue of glycoproteins containing N-acetylgalactosamine.Neurobiology, 5, 339–346.PubMedGoogle Scholar
  12. Brunngraber, E.G., Davis, L.G., Javaid, J.I. & Berra, B. (1976). Glycoprotein catabolism in brain tissue in the lysosomal enzyme deficiency diseases.Advances in Experimental Medicine and Biology, 68, 31–48.PubMedGoogle Scholar
  13. Brydon, W.G., Merrick, M.V., & Hannan, J. (1987). Absorbed dose from14C xylose and14C mannose.British Journal of Radiology, 60, 563–566.PubMedCrossRefGoogle Scholar
  14. Burgess, A.P. & Gruzelier, J.H. (2000). Short duration power changes in the EEG during recognition memory for words and faces.Psychophysiology, 37, 596–605.PubMedCrossRefGoogle Scholar
  15. Cooper, R., Osselton, J., & Shaw, J. (1980). EEG Technology, Ed. 3rd, Butterworths, London.Google Scholar
  16. Druse, M.J., Tonetti, D.A., & Smith, D.M. Jr. (1982) Effects of maternal nutritional stress on synaptic plasma membrane proteins and glycoproteins in offspring.Experimental Neurology, 78, 99–111.PubMedCrossRefGoogle Scholar
  17. Dykman, K.D. & Dykman, R.A. (1998). Effect of nutritional supplements on attentional deficit hyperactivity disorder.Integrative Physiological & Behavioral Science, 33, 49–60.CrossRefGoogle Scholar
  18. Flowers, H.M. (1981). Chemistry and biochemistry of D- and L-fucose.Advances in Carbohydrate Chemistry and Biochemistry, 39: 279–345.PubMedCrossRefGoogle Scholar
  19. Gannon, M.C., Khan, M.A. & Nuttall, F.Q. (2001). Glucose appearance rate after the ingestion of galactose.Metabolism, 50, 93–98.PubMedCrossRefGoogle Scholar
  20. Gold, P.E. (1995). Role of glucose in regulating the brain and cognition.American Journal of Clinical Nutrition, 61, 987S-995S.PubMedGoogle Scholar
  21. Greenhouse, S.W. & Geisser, S. (1959). On methods in the analysis of profile data.Psychometrica, 24, 95–112.CrossRefGoogle Scholar
  22. Hall, J.L., Gonder-Frederick, L.A., Chewning, W.W., Silveira, J. & Gold, P.E. (1989). Glucose enhancement of performance on memory tests in young and aged humans.Neuropsychologia 27, 1129–1138.PubMedCrossRefGoogle Scholar
  23. Hoffman, L.D. & Polich, J. (1998). EEG, ERPs and food consumption.Biological Psychology, 48, 139–151.PubMedCrossRefGoogle Scholar
  24. Kaufman, R.L. & Ginsburg, V. (1968). The metabolism of L-fucose by HeLa cells.Experimental Cell Research, 50, 127–132.PubMedCrossRefGoogle Scholar
  25. Kern, W., Peters, A., Fruehwald-Schultes, B., Deininger, E., Born, J. & Fehn, H. (2001) Improving influence of insulin on cognitive functions in humans.Neuroendocrinology, 74, 270–280.PubMedCrossRefGoogle Scholar
  26. Knott, V., Messier, C., Mahoney, C., & Gagnon, M. (2001). Glucose and glucoregulatory modulation of memory scanning, event-related potentials and EEG in elderly subjects.Neuropsychobiology, 44, 156–166.PubMedCrossRefGoogle Scholar
  27. Korol, D.L. & Gold, P.E. (1998). Glucose, memory, and aging.American Journal of Clinical Nutrition, 67, 764S-771S.PubMedGoogle Scholar
  28. LaFrance, C. & Dumont, M. (2000). Diurnal variations in the waking EEG: comparisons with sleep latency and subjective alertness.Journal of Sleep Research, 9, 243–248.PubMedCrossRefGoogle Scholar
  29. Lindsley, D. & Wicke, J. (1974). The electroencephalogram: Autonomous electrical activity in man and animals. In: Bioelectric recording techniques: Part B. electroencephalography and human brain potentials (Thompson, R. & Patterson, M., eds.), Academic Press, New York.Google Scholar
  30. Lorenzo, I., Ramos, J., Arce, C., Guevera, M.A. & Corsi-Cabrera, M. (1995). Effect of total sleep deprivation on reaction time and waking EEG activity in man.Sleep, 18: 346–354.PubMedGoogle Scholar
  31. Manning, C.A., Stone, W.S., Korol, D.L., & Gold, P.E. (1998). Glucose enhancement of 24-h memory retrieval in healthy elderly humans.Behavorial Brain Research, 93, 71–76.CrossRefGoogle Scholar
  32. Margolis, R.K., Preti, C., Lai, D. & Margolis, R.U. (1976). Developmental changes in brain glycoproteins.Brain Research, 112, 363–369.PubMedCrossRefGoogle Scholar
  33. Marquardt, T., Luhn, K., & Srikrishna G. (1999). Correction of leukocyte adhesion deficiency type II with oral fucose.Blood, 94, 3976–3985.PubMedGoogle Scholar
  34. Martin, A., Rambal, C., Berger, V., Perier, S., & Louisot, P. (1998). Availability of specific sugars for glycoconjugate biosynthesis: a need for further investigations in man.Biochimie, 80, 75–86.PubMedCrossRefGoogle Scholar
  35. Mattson, A.J., Sheer, D.E. & Fletcher, J.M. (1992). Electrophysiological evidence of lateralized disturbances in children with learning disabilities.Journal of Clinical and Experimental Neuropsychology, 14, 707–716.PubMedCrossRefGoogle Scholar
  36. Messier, C., Gagnon, M., & Knott, V. (1997). Effect of glucose and peripheral glucose regulation on memory in the elderly.Neurobiology of Aging, 18, 297–304.PubMedCrossRefGoogle Scholar
  37. Murray, R.K., Granner, D.K., Mayes, P.A., & Rodwell, V.W. (2003).Harper's Illustrated Biochemistry. Ed. 26th Lange Medical Books/McGraw-Hill, New York, NY, pp. 474, 167, 514–534.Google Scholar
  38. Penfield, W. & Jasper, H. (1954). Epilepsy and the functional anatomy of the human brain. Little Brown, Boston, MA.Google Scholar
  39. Petry, K.G. & Reichardt, J.K. (1998). The fundamental importance of human galactose metabolism: lessons from genetics and biochemistry.Trends in Genetics, 14, 98–102.PubMedCrossRefGoogle Scholar
  40. Pivik, R.T. (2000) Sleep and dreaming. In: Handbook of Psychophysiology (Cacioppo, J.T., Tassinary, L.G. & Bersnston, G.G., eds.), pp. 687–718. Cambridge Univ. Press, U.K.Google Scholar
  41. Pivik, R.T. & Harman, K.A. (1995). Reconceptualization of EEG alpha activity as an index of arousal during sleep: all alpha is not equal.Journal of Sleep Research, 4, 131–137.PubMedCrossRefGoogle Scholar
  42. Service, R. (2001).After the Fall. Science, 291, 2941.Google Scholar
  43. Sheer, D.E. (1984). Focused arousal, 40 hertz EEG and dysfunction. In:Self-Regulation of the Brain and Behavior (Elbert, T., ed.), pp. 63–84. Springer-Verlag, New York.Google Scholar
  44. Smith, A., Kendrick, A., Maben, A. & Salmon, J. (1994). Effects of breakfast and caffeine on cognitive performance, mood and cardiovascular functioning.Appetite, 22, 39–55.PubMedCrossRefGoogle Scholar
  45. Spydell, J.D. & Sheer, D.E. (1982). Effect of problem solving on right and left hemisphere 40 hertz EEG activity.Psychophysiology, 10, 420–425.CrossRefGoogle Scholar
  46. Stella, H., Service, R. & Schuromi, P. (2001). Cinderella's coach is ready.Science, 291, 2237.Google Scholar
  47. Talent, J.M., Gracy, R.W. (1996). Pilot study of oral polymeric N-acetyl-D-glucosamine as a potential treatment for patients with osteoarthritis.Clinical Therapeutics, 18, 1184–1190.PubMedCrossRefGoogle Scholar
  48. Tamburrano, G., Lala, A., Locuratolo, N., Leonetti, F. Sbraccia, P., Giaccari, A., Busco, S. & Porcu, S. (1988). Electroencephalography and visually evoked potentials during moderate hypoglycemia.Journal of Clinical Endocrinology and Metabolism, 66, 1301–1306.PubMedCrossRefGoogle Scholar
  49. Walter, W.G. (1953). The Living Brain, Norton, New York.Google Scholar
  50. Webster, J.C. & Klingman, J.D. (1980). Incorporation of radio-labelled sugars into synaptic, junctional macromolecules from chick brain.Brain Research Bulletin, 5, 31–34.PubMedCrossRefGoogle Scholar
  51. Wiese, T.J., Dunlap, J.A., & Yorek, M.A. (1997). Effect of L-fucose and D-glucose concentration of L-fucoprotein metabolism in human Hep G2 cells and changes in fucosyltransferase and alpha-L-fucosidase activity in liver of diabetic, rats.Biochimia et Biophysica Acta, 1335, 61–72.Google Scholar

Copyright information

© Springer 2004

Authors and Affiliations

  • Chenghua Wang
    • 1
  • Joanne S. Szabo
    • 2
  • Roscoe A. Dykman
    • 3
  1. 1.Rotman Research InstituteUSA
  2. 2.University of Arkansas for Medical SciencesUSA
  3. 3.Arkansas Children’s Nutrition CenterLittle Rock

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