Archives of Toxicology

, Volume 70, Issue 2, pp 119–123 | Cite as

A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat

  • Milan Jokanović
  • Matej Maksimović
Original Investigation


This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The effectiveness of trimedoxime, obidoxime, pralidoxime and HI-6, given with atropine and diazepam, was tested in the treatment of poisoning with 2 LD50 of the insecticides. It was shown that the oximes were potent antidotes in poisoning with phosphate insecticides. Obidoxime, pradidoxime and HI-6 had low effectiveness in the treatment of poisoning with phosphonates and phosphorothiolates. However, none of the oximes was an effective antidote in poisoning with dimethoate and pyridafenthion. Trimedoxime was the most effective oxime in the treatment of insecticide poisoning, being successful especially at the lowest tested doses.

Key words

Treatment of poisoning Antidotes Organophosphorus insecticides Oximes Toxicity Trimedoxime Obidoxime Pralidoxime HI-6 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Milan Jokanović
    • 1
  • Matej Maksimović
    • 2
  1. 1.Istituto di Medicina del LavoroUniversita degli Studi di PadovaPadovaItaly
  2. 2.Department of ToxicologyFaculty of PharmacyBelgradeYugoslavia

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