The Indian Journal of Pediatrics

, Volume 72, Issue 11, pp 935–938 | Cite as

Efficacy of tyndalizedLactobacillus acidophilus in acute diarrhea

  • Vikrant Khanna
  • Seema Alam
  • Ashraf Malik
  • Abida Malik
Original Article

Abstract

Objective : A double-blind randomized controlled-trial was done to evaluate the efficacy of tyndalizedLactobacillus acidophilus in acute diarrhea.Methods : All children from 6 months to 12 years with acute diarrhea were included.Lactobacillus acidophilus/placebo was given to the children for 3 days with ORS and feeds. Intake-output was recorded 4 hourly. Of the 98 children, 48 receivedlactobacillus and 50 the placebo.Results : ORS consumed, frequency of stools, duration of diarrhea, time for rehydration, hospital stay, weight gain and IVF needed were comparable in the two study groups. There were 4 treatment failures in thelactobacillus group and none in the placebo group (OR 0.92,95%CI 0.84–0.99). In the rotaviral diarrhea and in those who had diarrhea of less then 60 hours the difference did not reach statistical significance.Conclusion : There is no significant benefit of tyndalizedLactobacillus acidophilus in acute diarrhea.

Key words

Probiotics Tyndalized Lactobacillus acidophilus Acute diarrhea 

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Copyright information

© Dr. K C Chaudhuri Foundation 2005

Authors and Affiliations

  • Vikrant Khanna
    • 2
  • Seema Alam
    • 1
    • 2
  • Ashraf Malik
    • 1
    • 2
  • Abida Malik
    • 1
    • 2
  1. 1.Department of MicrobiologyJN Medical College, Aligarh Muslim UniversityAligarhIndia
  2. 2.Department of PediatricsJN Medical College, Aligarh Muslim UniversityAligarhIndia

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