Journal of Genetics

, Volume 83, Issue 2, pp 113–115 | Cite as

Benefits of being biased!

Research Commentary


codon bias alcohol dehydrogenase Darwinian fitness Drosophila melanogaster 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Akashi H. 1994 Synonymous codon usage inDrosophila melanogaster: natural selection and translational accuracy.Genetics 136, 927–935.PubMedGoogle Scholar
  2. Akashi H. 1995 Inferring weak selection from patterns of polymorphism and divergence at 'silent' sites inDrosophila DNA.Genetics 139, 1067–1076.PubMedGoogle Scholar
  3. Akashi H. 1996 Molecular evolution betweenDrosophila melanogaster andD. simulans: reduced codon bias, faster rates of amino acid substitution, and larger proteins inD. melanogaster.Genetics 144, 1297–1307.Google Scholar
  4. Bulmer M. 1991 The selection-mutation-drift theory of synonymous codon usage.Genetics 129, 897–907.PubMedGoogle Scholar
  5. Carlini D. B. 2004 Experimental reduction of codon bias in theDrosophila alcohol dehydrogenase gene results in decreased ethanol tolerance of adult flies.J. Evol. Biol. 17, 779–785.PubMedCrossRefGoogle Scholar
  6. Carlini, D. B. and Stephan W. 2003In vivo introduction of unpreferred synonymous codons into theDrosophila Adh gene results in reduced levels of ADH protein.Genetics 163, 239–243.PubMedGoogle Scholar
  7. Duret L. and Mouchiroud D. 1999 Expression pattern and, surprisingly, gene length shape codon usage inCaenorhabditis, Drosophila, and Arabidopsis.Proc. Natl. Acad. Sci. USA 96, 4482–4487.PubMedCrossRefGoogle Scholar
  8. King J. L. and Jukes T. H. 1969 Non-Darwinian evolution.Science 164, 788–798.PubMedCrossRefGoogle Scholar
  9. Kurland C. G. 1987 Strategies for efficiency and accuracy in gene expression. 1. The major codon preference: a growth optimization strategy.Trends Biochem. Sci. 12, 126–128.CrossRefGoogle Scholar
  10. McVean G. A. T. and Vieira J. 2001 Inferring parameters of muta tion, selection, and demography from patterns of synonymous site evolution inDrosophila.Genetics 157, 245–257.PubMedGoogle Scholar
  11. Moriyama E. N. and Powell J. R. 1997 Codon usage bias and tRNA abundance inDrosophila.J. Mol. Evol. 45, 514–523.PubMedCrossRefGoogle Scholar
  12. Nakamura Y., Gojobori, T. and Ikemura, T. 2000 Codon usage tabu lated from the international DNA sequence database: status for the year 2000.Nucleic Acids Res. 28, 292.PubMedCrossRefGoogle Scholar
  13. Powell J. R. and Moriyama E. N. 1997 Evolution of codon usage bias inDrosophila.Proc. Natl. Acad. Sci. USA 94, 7784–7790.PubMedCrossRefGoogle Scholar
  14. Precup J. and Parker J. 1987 Missense misreading of asparagine codons as a function of codon identity and context.J. Biol. Chem. 262, 11351–11356.PubMedGoogle Scholar
  15. Sörensen M. A., Kurland C. G. and Pedersen S. 1989 Codon usage determines translation rate inEscherichia coli.J. Mol. Biol. 207, 365–377.PubMedCrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2004

Authors and Affiliations

  1. 1.Evolutionary Biology Laboratory, Evolutionary & Organismal Biology UnitJawaharlal Nehru Centre for Advanced Scientific ResearchBangaloreIndia

Personalised recommendations