The Indian Journal of Pediatrics

, Volume 70, Issue 4, pp 307–309 | Cite as

Microalbuminuria as a predictor of early glomerular injury in children with sickle cell disease

  • Vikram Datta
  • Janaki Raju Ayengar
  • Shilpaja Karpate
  • Pushpa Chaturvedi
Original Article


Objective : A cross sectional study was carried out to determine the prevalence of microalbuminuria in the pediatric patients with sickle cell disease.Methods : The study was carried out on 64 pediatric patients aged less than 14 years with documented HbSS, HbAS and HbS beta thalassemia, Microalbuminuria was estimated using single radial immuno diffusion technique. Majority of the study subjects were of HbSS type. 38.5% had symptoms for >2 years. 18.8% of the study population had significant microalbuminuria (19.2% of SS types and 18.8% of Hb AS types).Result : Microalbuminuria excretion was significantly more in patients >9 years of age as compared to young patients (p<0.05). Mean serum creatinine levels did not show any significant difference in the various study groups.Conclusion : Microalbuminuria estimation is a very important clinical marker of preclinical glomerular damage in patients with sickle cell disease. Its estimation would help in the early detection of such patients and prompt initiation of therapy.

Key words

Sickle cell Microalbumin Glomerulus Kidney 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bourke E. The kidney in sickle cell disease.J Assoc Acad Minor Phys 1992; 3(2): 41–15.PubMedGoogle Scholar
  2. 2.
    Aoki RY, Saad S. Microalbuminuria in sickle cell disease.Braz J Med Biol Res 1990; 23 (11): 1103–1106.PubMedGoogle Scholar
  3. 3.
    Mogensen CE, Hansen KW, Nielsen S, Pedersen MM, Rehling M, Schmitz A. Monitoring diabetic nephropathy: Glomerular filtration rate and abnormal albuminuria in diabetic renal disease – Reproductivity, progression and efficacy of antihypertensive intervention.Am J Kidney Dis 1993; 22(1): 174–187.PubMedGoogle Scholar
  4. 4.
    Guasch A. Sickle Cell Information Center Guidelines-Proteinuria and renal insufficiency. Available (online): http:/ / Scholar
  5. 5.
    Sesso R, Almeida MA, Figueiredo MS, Bordin JO. Renal dysfunction in patients with sickle cell anemia or sickle cell trait.Braz J Med Biol Res 1998; 31(10): 1257–1262.PubMedCrossRefGoogle Scholar
  6. 6.
    Wigfall DR, Ware RE, Burchinal MR, Kinney TR, Foreman JW. Prevelance and clinical correlates of glomerulopathy in children with sickle ceU disease.J Pediatr 2000; 136 (6): 749–753.PubMedCrossRefGoogle Scholar
  7. 7.
    Dharnidharka VR, Dabbagh S, Atiyeh B, Simpson P, Sarnaik S. Prevalence of microalbuminuria in children with sickle cell disease.Pediatr Nephrol 1998; 12(6): 475–478.PubMedCrossRefGoogle Scholar
  8. 8.
    Allon M. Renal abnormalities in sickle cell disease.Arch Intern Med 1990; 150(3): 501–504.PubMedCrossRefGoogle Scholar
  9. 9.
    Allon M, Lawson L, Eckman JR, Delaney V, Bourke E. Effects of non-steroidal anti-inflammatory drugs on renal function in sickle cell anemia.Kidney Int 1988; 34:500–506.PubMedCrossRefGoogle Scholar
  10. 10.
    Verani RR, Conley SB. Sickle cell glomerulopathy with focal segmental glomerulosclerosis.Child Nephrol Urol 1991; 11 (4): 206–208.PubMedGoogle Scholar
  11. 11.
    Tejani A, Phadke K, Adamson O, Nicastri A, Chen CK, Sen D. Renal lesions in sickle cell nephropathy in children.Nephron 1985; 39 (4): 352–355.PubMedCrossRefGoogle Scholar
  12. 12.
    Guasch A. Sickle Cell Information Center Guidelines-Proteinuria and renal insufficiency. Available (online): http:/ / Scholar
  13. 13.
    Falk RJ, Scheinman J, Phillips G, Orringer E, Johnson A, Jennette JC. Prevalence and pathological features of sickle cell nephropathy and response to angiotensin-converting enzyme.N Engl J Med 1992; 2; 326(14):910–915.CrossRefGoogle Scholar
  14. 14.
    Sherwood JB, Goldwasser E, Chilcote R, Carmichael LD, Nagel RL. Sickle cell anemia patients have low erythropoietin levels for their degree of anemia.Blood 1986; 67:46–49.PubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2003

Authors and Affiliations

  • Vikram Datta
    • 1
  • Janaki Raju Ayengar
    • 1
  • Shilpaja Karpate
    • 1
  • Pushpa Chaturvedi
    • 1
  1. 1.Department of PediatricsMahatma Gandhi Institute of Medical SciencesMaharashtraIndia

Personalised recommendations