Post-resuscitation management of asphyxiated neonates
- 101 Downloads
Perinatal asphyxia is one of the common causes of neonatal mortality. Data from National Neonatal Perinatal database suggest that perinatal asphyxia contributes to almost 20% of neonatal deaths in India. Failure to initiate or sustain respiration after birth has been defined as criteria for the diagnosis of asphyxia by WHO. Perinatal asphyxia results in hypoxic injury to various organs including kidneys, lungs and liver but the most serious effects are seen on the central nervous system. Levene’s classification is a useful clinical tool for grading the severity of hypoxic ischemic encephalopathy. Good supportive care is essential in the first 48 hours after asphyxia to prevent ongoing brain injury in the penumbra region. Strict monitoring and prompt correction is needed for common problems including temperature maintenance, blood sugars, blood pressure and oxygenation. Phenobarbitone is the drug of choice for the treatment of convulsions.
Key wordsAsphyxia Central nervous system Neonates
Unable to display preview. Download preview PDF.
- 1.Costello A, Francis V, Byrne A, Puddephatt C. State of the world’s newborns. Kinetik Communications 2001.Google Scholar
- 2.World Health Organizaton. Perinatal mortality: a listing of available information. FRH/MSM.96.7. Geneva: WHO, 1996.Google Scholar
- 3.Report of the National Neonatal Perinatal Database (National Neonatology Forum, India) 2000Google Scholar
- 7.Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress: A clinical and electroencephalographic study.Arch Neurol 1976; 33: 695–706.Google Scholar
- 8.Levene MI. The asphyxiated newborn infant. In Levene MI, Lilford RJ, eds.Fetal and Neonatal Neurology and Neuro-surgery. Edinburgh, Churchil Livingstone 1995; 405–426.Google Scholar
- 9.Du-Pleiss AJ, Johnston MV. Hypoxic ischemic injury in newborn: cellular mechanism and potential strategies for neuroprotection.Clinics in Perinatology 1997; 29: 627–654.Google Scholar